Prevention of ovarian damage induced by cyclophosphamide in adult female mice by hormonal manipulations

Página do item simplificado
dc.contributor.authorBudel V.
dc.contributor.authorKiss R.
dc.contributor.authorDe Launoit Y.
dc.contributor.authorDanguy A.
dc.contributor.authorAtassi G.
dc.contributor.authorPasteels J.L.
dc.contributor.authorParidaens R.
dc.date.accessioned2024-03-13T01:47:46Z
dc.date.available2024-03-13T01:47:46Z
dc.date.issued1988
dc.description.abstractDoses of 10 or 20 mg cyclophosphamide/kg body weight were administered daily to mice for up to 20 days. This caused significant reduction in the incidence of prenatal (developing) follicles and significant increases in atretic (degenerating) follicles with the ovaries. Attempts to prevent cyclophosphamide-induced damage by simultaneous treatment with oestrogen alone, oestrogen plus progesterone, or danazol (a synthetic androgen) demonstrated that danazol effectively prevented the ovarian damage. The efficacy of danazol was considered to be due to its ability to inhibit LH/FSH secretion and, indirectly, the development of new ovarian follicles.
dc.description.firstpage625
dc.description.issuenumber2
dc.description.lastpage633
dc.description.volume84
dc.identifier.doi10.1530/jrf.0.0840625
dc.identifier.issn0022-4251
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/38080
dc.relation.ispartofJournal of Reproduction and Fertility
dc.rightsAcesso Aberto
dc.titlePrevention of ovarian damage induced by cyclophosphamide in adult female mice by hormonal manipulations
dc.typeArtigo
local.scopus.citations9
local.scopus.eid2-s2.0-0023698691
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0023698691&origin=inward
Arquivos
Coleções
Artigos de periódico