Antifungal derivatives from Piper mollicomum and P. lhotzkyanum (PIPERACEAE)
Tipo
Artigo
Data de publicação
2007
Periódico
Quimica Nova
Citações (Scopus)
28
Autores
Lago J.H.G.
Young M.C.M.
Reigada J.B.
Soares M.G.
Roesler B.P.
Kato M.J.
Young M.C.M.
Reigada J.B.
Soares M.G.
Roesler B.P.
Kato M.J.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Bioguided fractionation of the extracts from leaves of Piper mollicomum and Piper lhotzkyanum against the fungi Cladosporium cladosporioides and C. sphaerospermum afforded seven bioactive compounds, four being chromenes: methyl 2,2-dimethyl-2H-chromene-6-carboxylate, methyl 8-hydroxy-2,2-dimethyl-2H- chromene-6-carboxylate, 2-methyl-2-[4′-methyl-3′-pentenyl]-2H-1- benzopyran-6-carboxylic acid, 2,2-dimethyl-2H-chromene-6-carboxylic acid, one a dihydrochalcone: 2′,6′-dihydroxy-4′-methoxydihydrochalcone, and two flavanones: 7-methoxy-5,4'-dihydroxy-flavanone and 7,4′-dimethoxy- 5-hydroxy-flavanone. The structures of the bioactive isolated derivatives were elucidated by interpretation of their NMR data [1H and 13C (BBD, DEPT 135°)], and mass spectral data as well as by comparison with data described in the literature.