Enhancement of affective processing induced by bifrontal transcranial direct current stimulation in patients with major depression

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorZanao T.A.
dc.contributor.authorVanderhasselt M.-A.
dc.contributor.authorValiengo L.
dc.contributor.authorDe Oliveira J.F.
dc.contributor.authorBoggio P.S.
dc.contributor.authorLotufo P.A.
dc.contributor.authorBensenor I.M.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:02:47Z
dc.date.available2024-03-13T01:02:47Z
dc.date.issued2014
dc.description.abstractObjective Our aim was to evaluate whether one single section of transcranial direct current stimulation (tDCS), a neuromodulatory technique that noninvasively modifies cortical excitability, could induce acute changes in the negative attentional bias in patients with major depression. Subjects and Methods Randomized, double-blind, sham-controlled, parallel design enrolling 24 age-, gender-matched, drug-free, depressed subjects. Anode and cathode were placed over the left and right dorsolateral prefrontal cortex. We performed a word Emotional Stroop Task collecting the response times (RTs) for positive-, negative-, and neutral-related words. The emotional Stroop effect for negative vs. neutral and vs. positive words was used as the measure of attentional bias. Results At baseline, RTs were significantly slower for negative vs. positive words. We found that active but not sham tDCS significantly modified the negative attentional bias, abolishing slower RT for negative words. Conclusion Active but not sham tDCS significantly modified the negative attentional bias. These findings add evidence that a single tDCS session transiently induces potent changes in affective processing, which might be one of the mechanisms of tDCS underlying mood changes. © 2013 International Neuromodulation Society.
dc.description.firstpage138
dc.description.issuenumber2
dc.description.lastpage142
dc.description.volume17
dc.identifier.doi10.1111/ner.12080
dc.identifier.issn1525-1403
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36510
dc.relation.ispartofNeuromodulation
dc.rightsAcesso Restrito
dc.subject.otherlanguageaffective processing
dc.subject.otherlanguagecognition
dc.subject.otherlanguagedepressive disorder
dc.subject.otherlanguageemotional Stroop effect
dc.subject.otherlanguageprefrontal cortex
dc.subject.otherlanguagetranscranial direct current stimulation
dc.titleEnhancement of affective processing induced by bifrontal transcranial direct current stimulation in patients with major depression
dc.typeArtigo
local.scopus.citations58
local.scopus.eid2-s2.0-84897107823
local.scopus.subjectAdolescent
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAttention
local.scopus.subjectDepressive Disorder, Major
local.scopus.subjectDouble-Blind Method
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectPhotic Stimulation
local.scopus.subjectPrefrontal Cortex
local.scopus.subjectReaction Time
local.scopus.subjectTranscranial Magnetic Stimulation
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84897107823&origin=inward
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