Platelet count and clinical profile of anticardiolipin positive leg ulcers Contagem de plaquetas e caracterização clínica de úlceras de perna anticardiolipinas positivas

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dc.contributor.authorSkare T.L.
dc.contributor.authorRibas C.A.P.M.
dc.contributor.authorMalafaia O.
dc.contributor.authorFilho J.M.R.
dc.contributor.authorNassif P.A.N.
dc.contributor.authordo Nascimento M.M.
dc.contributor.authorPachnicki J.P.A.
dc.date.accessioned2024-03-13T01:35:48Z
dc.date.available2024-03-13T01:35:48Z
dc.date.issued2009
dc.description.abstractObjective: To study the prevalence of anticardiolipin antibodies in patients with venous, diabetic and arterial leg ulcers and to verify if platelet count, previous history of venous thrombosis, obstetrical history and the finding of livedo reticularis are markers of this autoantibody positivity. Methods: 151 patients with leg ulcer (81 with venous, 50 with diabetic and 20 with arterial ulcers) and 150 controls were included. In both groups search for the presence of IgG and IgM anticardiolipin and platelet count was done. In the leg ulcer group demographic data, obstetrical history, previous history of venous thrombosis as well as presence of livedo reticularis by physical examination were pointed out. Data was grouped in contingency and frequency tables and the tests of Fisher and chi-squared were used for nominal variables and Mann Whitney and Kruskall Wallis for numerical variables. The adopted significance was of 5%. Results: It was found an anticardiolipin prevalence of 7.2% (n=12) in the leg ulcer group and of 1.3% (n=2) in the control group (p=0.01). Leg ulcer patients with anticardiolipin did not differ from those without it in gender (p=0.98), previous history of venous thrombosis (p=0.69), previous history of abortions (p=0.67) and platelet count (p=0.67). Only two patients had livedo reticularis which precluded any conclusion on this data. Conclusion: There is an increased prevalence of anticardiolipin antibodies in the general population with leg ulcers. Clinical characteristics of ulcers as well as platelet count do not help in the identification of these patients.
dc.description.firstpage420
dc.description.issuenumber5
dc.description.lastpage424
dc.description.volume36
dc.identifier.doi10.1590/s0100-69912009000500010
dc.identifier.issn1809-4546
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37423
dc.relation.ispartofRevista do Colegio Brasileiro de Cirurgioes
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntibody anticardiolipin
dc.subject.otherlanguageDiabetic foot
dc.subject.otherlanguageLeg ulcer
dc.subject.otherlanguageSkin ulcer
dc.subject.otherlanguageVenous insufficiency
dc.titlePlatelet count and clinical profile of anticardiolipin positive leg ulcers Contagem de plaquetas e caracterização clínica de úlceras de perna anticardiolipinas positivas
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-76049093366
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=76049093366&origin=inward
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