Foot function in rheumatoid arthritis patients: a cross-sectional study

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dc.contributor.authorde Andrade A.P.
dc.contributor.authorInoue E.N.
dc.contributor.authorNisihara R.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-12T23:56:03Z
dc.date.available2024-03-12T23:56:03Z
dc.date.issued2018
dc.description.abstract© 2018, International League of Associations for Rheumatology (ILAR).Rheumatoid arthritis (RA) is a chronic disease that affects mainly small joints from hands and feet. The aims of this study were to analyze the prevalence of foot involvement in a sample of Brazilian RA patients and to explore the influence of disease variables such as inflammatory activity, serological, and epidemiological profile in this type of involvement. One hundred RA patients and 100 healthy controls paired for gender, age, and body mass index answered the FFI-BR (Foot Functional Index–Brazilian version) that evaluates foot function. RA patients had epidemiological and clinical data collection upon direct questioning and chart review. C-reactive protein (CRP), ESR (erythrocyte sedimentation rate), and DAS28-ESR were used to measure disease activity. In the RA sample, 98% had foot pain versus 76% in the controls (p < 0.0001; OR = 15.4; 95% CI = 3.4–67.5); 96% had some difficulty in function versus 66% of controls (p < 0.0001; OR = 12.3; 95% CI = 4.1–36.5); and 73% had some incapacity versus 20% of controls (p < 0.0001; OR = 10.8; 95% CI = 5.5–20.9). Values of FFI-BR showed correlation with ESR (p = 0.006), CRP (p = 0.01), and DAS28-ESR (p < 0.0001). No association between FFI-BR total score and gender, ethnic background, positive rheumatoid factor, tobacco exposure, and any of used medications was found (all p = ns). The majority of RA patients suffers from foot problems and was associated with inflammatory biomarkers. The control of inflammatory activity may help in the treatment of this problem.
dc.description.firstpage3427
dc.description.issuenumber12
dc.description.lastpage3430
dc.description.volume37
dc.identifier.doi10.1007/s10067-018-4215-y
dc.identifier.issn1434-9949
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35427
dc.relation.ispartofClinical Rheumatology
dc.rightsAcesso Restrito
dc.subject.otherlanguageC-reactive protein
dc.subject.otherlanguageFoot Functional Index–Brazilian version
dc.subject.otherlanguageRheumatoid arthritis
dc.titleFoot function in rheumatoid arthritis patients: a cross-sectional study
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-85049917337
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectArthritis, Rheumatoid
local.scopus.subjectBiomarkers
local.scopus.subjectBlood Sedimentation
local.scopus.subjectBrazil
local.scopus.subjectC-Reactive Protein
local.scopus.subjectCase-Control Studies
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectFemale
local.scopus.subjectFoot
local.scopus.subjectHealth Status
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectRheumatoid Factor
local.scopus.subjectSeverity of Illness Index
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85049917337&origin=inward
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