Cognitive, mood, and electroencephalographic effects of noninvasive cortical stimulation with weak electrical currents

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dc.contributor.authorTadini L.
dc.contributor.authorEl-Nazer R.
dc.contributor.authorBrunoni A.R.
dc.contributor.authorWilliams J.
dc.contributor.authorCarvas M.
dc.contributor.authorBoggio P.
dc.contributor.authorPriori A.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:11:13Z
dc.date.available2024-03-13T01:11:13Z
dc.date.issued2011
dc.description.abstractOBJECTIVES: The use of noninvasive cortical electrical stimulation with weak currents has significantly increased in basic and clinical human studies. Initial, preliminary studies with this technique have shown encouraging results; however, the safety and tolerability of this method of brain stimulation have not been sufficiently explored yet. The purpose of our study was to assess the effects of direct current (DC) and alternating current (AC) stimulation at different intensities in order to measure their effects on cognition, mood, and electroencephalogram. METHODS: Eighty-two healthy, right-handed subjects received active and sham stimulation in a randomized order. We conducted 164 ninety-minute sessions of electrical stimulation in 4 different protocols to assess safety of (1) anodal DC of the dorsolateral prefrontal cortex (DLPFC); (2) cathodal DC of the DLPFC; (3) intermittent anodal DC of the DLPFC and; (4) AC on the zygomatic process. We used weak currents of 1 to 2 mA (for DC experiments) or 0.1 to 0.2 mA (for AC experiment). RESULTS: We found no significant changes in electroencephalogram, cognition, mood, and pain between groups and a low prevalence of mild adverse effects (0.11% and 0.08% in the active and sham stimulation groups, respectively), mainly, sleepiness and mild headache that were equally distributed between groups. CONCLUSIONS: Here, we show no neurophysiological or behavioral signs that transcranial DC stimulation or AC stimulation with weak currents induce deleterious changes when comparing active and sham groups. This study provides therefore additional information for researchers and ethics committees, adding important results to the safety pool of studies assessing the effects of cortical stimulation using weak electrical currents. Further studies in patients with neuropsychiatric disorders are warranted. © 2011 Lippincott Williams & Wilkins, Inc.
dc.description.firstpage134
dc.description.issuenumber2
dc.description.lastpage140
dc.description.volume27
dc.identifier.doi10.1097/YCT.0b013e3181e631a8
dc.identifier.issn1095-0680
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36984
dc.relation.ispartofJournal of ECT
dc.rightsAcesso Restrito
dc.subject.otherlanguageadverse effects
dc.subject.otherlanguagebrain stimulation
dc.subject.otherlanguagesafety
dc.subject.otherlanguagetranscranial direct current stimulation
dc.titleCognitive, mood, and electroencephalographic effects of noninvasive cortical stimulation with weak electrical currents
dc.typeArtigo
local.scopus.citations58
local.scopus.eid2-s2.0-79958824085
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79958824085&origin=inward
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