Antinociceptive and anti-inflammatory effects of lantana camara L. Extract in mice Efeitos antinociceptivos do extrato de Lantana camara L. Em camundongos

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dc.contributor.authorSilva T.S.C.
dc.contributor.authorSuffredini I.B.
dc.contributor.authorRicci E.L.
dc.contributor.authorFernandes S.R.C.
dc.contributor.authorGoncalves V.J.R.
dc.contributor.authorRomoff P.
dc.contributor.authorLago J.H.G.
dc.contributor.authorBernardi M.M.
dc.date.accessioned2024-03-13T00:59:26Z
dc.date.available2024-03-13T00:59:26Z
dc.date.issued2015
dc.description.abstract© 2015, Instituto de Biociencias. All rights reserved.he Lantana camara L. belongs to the family Verbenaceae, which contains several active compounds in leaves and roots and which are reported to have medicinal and insecticidal properties. Studies of plants within the same family show the existence of anti-inflammatory activity in paw edema induced by carrageenan, serotonin and histamine and analgesic activity in the acetic acid writhing and tail-flick tests. The present study investigated whether the L. camara extract (ACE) also exerts these effects. The ACE toxicity was studied in male mice, and the percentage of mortality recorded 7 days after treatment was assessed. The ACE was evaluated as an antinociceptive agent in the hot plate, tail-flick and acetic acid writhing tests at a nontoxic dose of 1.0 g/Kg. The results showed that 1.5 g/Kg of ACE was not able to cause death, and doses of 3.0 and 4.0 g/Kg caused 50% and 60% death, respectively, in male mice. In all of the antinociceptive tests, 1 g/Kg of ACE markedly reduced responses to pain. Our findings suggest that ACE may have active anti-inflammatory and antinociceptive properties in much smaller doses than toxic.
dc.description.firstpage224
dc.description.issuenumber2
dc.description.lastpage229
dc.description.volume17
dc.identifier.doi10.1590/1983-084X/11_109
dc.identifier.issn1516-0572
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36325
dc.relation.ispartofRevista Brasileira de Plantas Medicinais
dc.rightsAcesso Aberto
dc.subject.otherlanguageAcetic acid writhing test
dc.subject.otherlanguageHot plate test
dc.subject.otherlanguageLantana camara
dc.subject.otherlanguageMice
dc.subject.otherlanguageTail-flick test
dc.titleAntinociceptive and anti-inflammatory effects of lantana camara L. Extract in mice Efeitos antinociceptivos do extrato de Lantana camara L. Em camundongos
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-84929317923
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84929317923&origin=inward
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