Treatment of depression with transcranial direct current stimulation (tDCS): A Review

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dc.contributor.authorNitsche M.A.
dc.contributor.authorBoggio P.S.
dc.contributor.authorFregni F.
dc.contributor.authorPascual-Leone A.
dc.date.accessioned2024-03-13T01:34:25Z
dc.date.available2024-03-13T01:34:25Z
dc.date.issued2009
dc.description.abstractMajor Depression Disorder (MDD) is usually accompanied by alterations of cortical activity and excitability, especially in prefrontal areas. These are reflections of a dysfunction in a distributed cortico-subcortical, bihemispheric network. Therefore it is reasonable to hypothesize that altering this pathological state with techniques of brain stimulation may offer a therapeutic target. Besides repetitive transcranial magnetic stimulation, tonic stimulation with weak direct currents (tDCS) modulates cortical excitability for hours after the end of stimulation, thus, it is a promising non-invasive therapeutic option. Early studies from the 1960s suggested some efficacy of DC stimulation to reduce symptoms in depression, but mixed results and development of psychotropic drugs resulted in an early abandonment of this technique. In the last years tDCS protocols have been optimized. Application of the newly developed stimulation protocols in patients with major depression has shown promise in few pilot studies. Further studies are needed to identify the optimal parameters of stimulation and the clinical and patient characteristics that may condition response to tDCS. © 2009 Elsevier Inc.
dc.description.firstpage14
dc.description.issuenumber1
dc.description.lastpage19
dc.description.volume219
dc.identifier.doi10.1016/j.expneurol.2009.03.038
dc.identifier.issn0014-4886
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37345
dc.relation.ispartofExperimental Neurology
dc.rightsAcesso Restrito
dc.subject.otherlanguageBrain stimulation
dc.subject.otherlanguageDepression
dc.subject.otherlanguageHumans
dc.subject.otherlanguagePrefrontal cortex
dc.subject.otherlanguagerTMS
dc.subject.otherlanguagetDCS
dc.subject.otherlanguageTherapy
dc.subject.otherlanguageTranscranial direct current stimulation
dc.subject.otherlanguageTranscranial magnetic stimulation
dc.titleTreatment of depression with transcranial direct current stimulation (tDCS): A Review
dc.typeArtigo de revisão
local.scopus.citations384
local.scopus.eid2-s2.0-68549125229
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=68549125229&origin=inward
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