Rheumatic Disease Autoantibodies in Patients with Autoimmune Thyroid Diseases

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dc.contributor.authorNisihara R.
dc.contributor.authorPigosso Y.G.
dc.contributor.authorPrado N.
dc.contributor.authorUtiyama S.R.R.
dc.contributor.authorDe Carvalho G.A.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-12T23:57:00Z
dc.date.available2024-03-12T23:57:00Z
dc.date.issued2018
dc.description.abstract© 2018 The Author(s) Published by S. Karger AG, Basel.Background: Patients with autoimmune thyroid diseases (ATD) such as Graves' disease (GD) and Hashimoto thyroiditis (HT) may have non-organ specific autoantibodies such as antinuclear antibodies (ANA) and rheumatoid factor (RF). Aim: To study the prevalence of rheumatic autoantibodies in a group of ATD patients without known rheumatic diseases and to evaluate its association with the patients' epidemiological and treatment profiles. To follow positive non-organ specific autoantibody-positive ATD individuals to investigate whether they will develop a rheumatic disorder. Methods: A sample of 154 ATD patients (70 HT and 84 GD; mean age 45.3 ± 14.2) had determination of ANA by immunofluorescence, using hep-2 cells as substrate, extractable nuclear antigen profile by ELISA kits and RF by latex agglutination. Epidemiological and treatment profiles were obtained through chart review. These patients were followed for the mean period of 5 years, between 2010 and 2015. Results: Positive ANA was found in 17.5% (27/154) of the patients: anti-Ro/SS-A in 4/154 (2.5%); anti-RNP in 4/154 (2.5%), and anti-La/SS-B in 3/154 (1.9%). None had anti-Sm antibodies. RF was detected in 12/154 (7.7%) of ATD patients and was more common in older individuals (p = 0.007). There was a positive association between the presence of RF and ANA (p = 0.03; OR 3.89; 95% CI 1.1-13.3). None of the patients with positive autoantibodies developed clinical rheumatic diseases during the period of observation. Conclusion: We found rheumatic autoantibodies in 17.5% of ATD patients without rheumatic diseases. None of them were associated with the appearance of clinical rheumatic disorder during the period of 5 years.
dc.description.firstpage332
dc.description.issuenumber4
dc.description.lastpage336
dc.description.volume27
dc.identifier.doi10.1159/000490569
dc.identifier.issn1423-0151
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35482
dc.relation.ispartofMedical Principles and Practice
dc.rightsAcesso Aberto
dc.subject.otherlanguageAutoimmunity
dc.subject.otherlanguageRheumatic diseases
dc.subject.otherlanguageThyroiditis
dc.titleRheumatic Disease Autoantibodies in Patients with Autoimmune Thyroid Diseases
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-85053017851
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAntibodies, Antinuclear
local.scopus.subjectAntithyroid Agents
local.scopus.subjectAutoantibodies
local.scopus.subjectEnzyme-Linked Immunosorbent Assay
local.scopus.subjectFemale
local.scopus.subjectFollow-Up Studies
local.scopus.subjectGraves Disease
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectPrevalence
local.scopus.subjectRheumatic Diseases
local.scopus.subjectRheumatoid Factor
local.scopus.subjectSurveys and Questionnaires
local.scopus.subjectThyroiditis, Autoimmune
local.scopus.subjectThyroxine
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053017851&origin=inward
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