A TRβ-selective agonist confers resistance to diet-induced obesity

Página do item simplificado
dc.contributor.authorAmorim B.S.
dc.contributor.authorUeta C.B.
dc.contributor.authorFreitas B.C.G.
dc.contributor.authorNassif R.J.
dc.contributor.authorGouveia C.H.D.A.
dc.contributor.authorChristoffolete M.A.
dc.contributor.authorMoriscot A.S.
dc.contributor.authorLancelloti C.L.
dc.contributor.authorLlimona F.
dc.contributor.authorBarbeiro H.V.
dc.contributor.authorDe Souza H.P.
dc.contributor.authorCatanozi S.
dc.contributor.authorPassarelli M.
dc.contributor.authorAoki M.S.
dc.contributor.authorBianco A.C.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-13T01:34:03Z
dc.date.available2024-03-13T01:34:03Z
dc.date.issued2009
dc.description.abstractThyroid hormone receptor β (TRβ also listed as THRB on the MGI Database)-selective agonists activate brown adipose tissue (BAT) thermogenesis, while only minimally affecting cardiac activity or lean body mass. Here, we tested the hypothesis that daily administration of the TRβ agonist GC-24 prevents the metabolic alterations associated with a hypercaloric diet. Rats were placed on a high-fat diet and after a month exhibited increased body weight (BW) and adiposity, fasting hyperglycemia and glucose intolerance, increased plasma levels of triglycerides, cholesterol, nonesterified fatty acids and interleukin-6. While GC-24 administration to these animals did not affect food ingestion or modified the progression of BW gain, it did increase energy expenditure, eliminating the increase in adiposity without causing cardiac hypertrophy. Fasting hyperglycemia remained unchanged, but treatment with GC-24 improved glucose tolerance by increasing insulin sensitivity, and also normalized plasma triglyceride levels. Plasma cholesterol levels were only partially normalized and liver cholesterol content remained high in the GC-24-treated animals. Gene expression in liver, skeletal muscle, and white adipose tissue was only minimally affected by treatment with GC-24, with the main target being BAT. In conclusion, during high-fat feeding treatment with the TRβ-selective agonist, GC-24 only partially improves metabolic control probably as a result of accelerating the resting metabolic rate. © 2009 Society for Endocrinology.
dc.description.firstpage291
dc.description.issuenumber2
dc.description.lastpage299
dc.description.volume203
dc.identifier.doi10.1677/JOE-08-0539
dc.identifier.issn0022-0795
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37324
dc.relation.ispartofJournal of Endocrinology
dc.rightsAcesso Restrito
dc.titleA TRβ-selective agonist confers resistance to diet-induced obesity
dc.typeArtigo
local.scopus.citations44
local.scopus.eid2-s2.0-70449421916
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=70449421916&origin=inward
Arquivos
Coleções
Artigos de periódico