Prevalence of the American College of Rheumatology hematological classification criteria and associations with serological and clinical variables in 460 systemic lupus erythematosus patients

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dc.contributor.authorSkare T.
dc.contributor.authorDamin R.
dc.contributor.authorHofius R.
dc.date.accessioned2024-03-13T00:59:16Z
dc.date.available2024-03-13T00:59:16Z
dc.date.issued2015
dc.description.abstract© 2015 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular.Objective: To study systemic lupus erythematosus in a Brazilian population using the American College of Rheumatology hematological classification criteria and report associations of the disease with serological and clinical profiles. Methods: This is a retrospective study of 460 systemic lupus erythematosus patients followed in a single rheumatologic center during the last 10 years. Hematological manifestations considered for this study were hemolysis, leukopenia, lymphocytopenia and thrombocytopenia. Results: The cumulative prevalences of leukopenia, thrombocytopenia, lymphocytopenia and hemolytic anemia were 29.8%, 21.08%, 17.7% and 8.4%, respectively. A higher percentage of patients with hemolysis had anticardiolipin IgM ( p-value = 0.002). Those with leukopenia had more lymphopenia ( p-value = 0.02), psychosis ( p-value = 0.01), thrombocytopenia (. p-value <0.0001) and anti-double stranded DNA antibodies ( p-value = 0.03). Patients with lymphopenia had more leukopenia (OR = 1.8; 95% CI = 1.01-3.29) and lupus anticoagulant antibodies (OR = 2.2; 95% CI = 1.16-4.39) and those with thrombocytopenia had more leukopenia (OR = 3.1; 95% CI = 1.82-5.44) and antiphospholipid syndrome (OR = 3.1; 95% CI = 1.28-7.87). Conclusion: The most common hematological finding was leukopenia and the least common was hemolysis. Associations of low platelet count and hemolysis were found with antiphospholipid syndrome and anticardiolipin IgM positivity, respectively. Leukopenia and lymphocytopenia are correlated and leukopenia is more common in systemic lupus erythematosus patients with psychosis, thrombocytopenia and anti-double stranded DNA.
dc.description.firstpage115
dc.description.issuenumber2
dc.description.lastpage119
dc.description.volume37
dc.identifier.doi10.1016/j.bjhh.2015.01.006
dc.identifier.issn1806-0870
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36315
dc.relation.ispartofRevista Brasileira de Hematologia e Hemoterapia
dc.rightsAcesso Aberto
dc.subject.otherlanguageHemolytic anemia
dc.subject.otherlanguageLeukopenia
dc.subject.otherlanguageSystemic lupus erythematosus
dc.subject.otherlanguageThrombocytopenia
dc.titlePrevalence of the American College of Rheumatology hematological classification criteria and associations with serological and clinical variables in 460 systemic lupus erythematosus patients
dc.typeArtigo
local.scopus.citations10
local.scopus.eid2-s2.0-84933676498
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84933676498&origin=inward
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