Ketamine causes poor maternal care in rats with postpartum depression and leads to few behavioral and neurochemical alterations on male offspring

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dc.contributor.authorZaccarelli-Magalhaes J.
dc.contributor.authorAbreu G.R.
dc.contributor.authorFukushima A.R.
dc.contributor.authorPantaleon L.P.
dc.contributor.authorRibeiro B.B.
dc.contributor.authorMunhoz C.
dc.contributor.authorManes M.
dc.contributor.authorde Lima M.A.
dc.contributor.authorMiglioli J.
dc.contributor.authorFlorio J.C.
dc.contributor.authorLebrun I.
dc.contributor.authorRicci E.L.
dc.contributor.authorSpinosa H.S.
dc.date.accessioned2024-03-12T19:06:53Z
dc.date.available2024-03-12T19:06:53Z
dc.date.issued2024
dc.description.abstract© 2023 Elsevier B.V.Ketamine is an anesthetic drug that also has antidepressant properties, with quick action. Despite the great number of studies showing its effectiveness as a treatment for major depression, there is little information about its effects on postpartum depression, as pharmacological treatments bring risks to the health of both mother and child. Thus, this study aimed to evaluate the effects of prolonged treatment with subanesthetic doses of ketamine in a rat model of postpartum depression. Female dams were induced to postpartum depression by the maternal separation model from lactating day (LD) 2–12. They were divided into four groups: one control and three experimental groups, which were treated with different doses of ketamine (5, 10 or 20 mg/kg) from LD 2–21 i.p. Maternal studies were conducted from LD5 to LD21 and the offspring studies from postnatal day 2 through 90. Ketamine causes poor maternal care, with few neurochemical alterations. However, the highest dose used in this study had an antidepressant effect. Regarding the male offspring, indirect exposure to ketamine through breast milk caused few behavioral changes during infancy, but they were not permanent, as they faded in adulthood. Nevertheless, this exposure was able to cause alterations in their monoaminergic neurotransmission systems that were found in both infancy and adulthood periods.
dc.description.volume459
dc.identifier.doi10.1016/j.bbr.2023.114799
dc.identifier.issn1872-7549
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/33937
dc.relation.ispartofBehavioural Brain Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntidepressant
dc.subject.otherlanguageMother-child bond
dc.subject.otherlanguageNMDA antagonist
dc.subject.otherlanguageOffspring development
dc.subject.otherlanguagePostpartum depression
dc.titleKetamine causes poor maternal care in rats with postpartum depression and leads to few behavioral and neurochemical alterations on male offspring
dc.typeArtigo
local.scopus.citations0
local.scopus.eid2-s2.0-85180105555
local.scopus.subjectAnimals
local.scopus.subjectAntidepressive Agents
local.scopus.subjectChild
local.scopus.subjectDepression
local.scopus.subjectDepression, Postpartum
local.scopus.subjectDepressive Disorder, Major
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectKetamine
local.scopus.subjectLactation
local.scopus.subjectMale
local.scopus.subjectMaternal Deprivation
local.scopus.subjectRats
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85180105555&origin=inward
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