Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

Página do item simplificado
dc.contributor.authorBocco B.M.
dc.contributor.authorFernandes G.W.
dc.contributor.authorLorena F.B.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorChristoffolete M.A.
dc.contributor.authorGrecco S.S.
dc.contributor.authorLancellotti C.L.
dc.contributor.authorRomoff P.
dc.contributor.authorLago J.H.G.
dc.contributor.authorBianco A.C.
dc.contributor.authorRibeiro M.O.
dc.date.accessioned2024-03-13T00:53:49Z
dc.date.available2024-03-13T00:53:49Z
dc.date.issued2016
dc.description.abstract© 2016, Associacao Brasileira de Divulgacao Cientifica. All rights reserved.Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.
dc.description.issuenumber3
dc.description.volume49
dc.identifier.doi10.1590/1414-431X20155003
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36006
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsAcesso Aberto
dc.subject.otherlanguageCaffeic acid
dc.subject.otherlanguageFerulic acid
dc.subject.otherlanguageMetabolic syndrome
dc.subject.otherlanguageObesity
dc.titleCombined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
dc.typeArtigo
local.scopus.citations19
local.scopus.eid2-s2.0-84956900882
local.scopus.subjectAnimals
local.scopus.subjectBaccharis
local.scopus.subjectCaffeic Acids
local.scopus.subjectCholesterol
local.scopus.subjectCoumaric Acids
local.scopus.subjectDiet, High-Fat
local.scopus.subjectDrug Therapy, Combination
local.scopus.subjectFatty Liver
local.scopus.subjectMale
local.scopus.subjectMetabolic Syndrome X
local.scopus.subjectMice, Inbred C57BL
local.scopus.subjectModels, Animal
local.scopus.subjectProtective Agents
local.scopus.subjectTriglycerides
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84956900882&origin=inward
Arquivos
Coleções
Artigos de periódico