Multifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine

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dc.contributor.authorMalagrino T.R.S.
dc.contributor.authorGodoy A.P.
dc.contributor.authorBarbosa J.M.
dc.contributor.authorLima A.G.T.
dc.contributor.authorSousa N.C.O.
dc.contributor.authorPedrotti J.J.
dc.contributor.authorGarcia P.S.
dc.contributor.authorPaniago R.M.
dc.contributor.authorAndrade L.M.
dc.contributor.authorDomingues S.H.
dc.contributor.authorSilva W.M.
dc.contributor.authorRibeiro H.
dc.contributor.authorTaha-Tijerina J.
dc.date.accessioned2024-03-12T19:14:51Z
dc.date.available2024-03-12T19:14:51Z
dc.date.issued2022
dc.description.abstract© 2022 by the authors. Licensee MDPI, Basel, Switzerland.In this work, flower-like molybdenum disulfide (MoS2 ) microspheres were produced with polyethylene glycol (PEG) to form MoS2-PEG. Likewise, gold nanoparticles (AuNPs) were added to form MoS2-PEG/Au to investigate its potential application as a theranostic nanomaterial. These nanomaterials were fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), photoelectron X-ray spectroscopy (XPS), Fourier-transformed infrared spectroscopy (FTIR), cyclic voltammetry and impedance spectroscopy. The produced hierarchical MoS2-PEG/Au microstructures showed an average diameter of 400 nm containing distributed gold nanoparticles, with great cellular viability on tumoral and non-tumoral cells. This aspect makes them with multifunctional characteristics with potential application for cancer diagnosis and therapy. Through the complete morphological and physicochemical characterization, it was possible to observe that both MoS2-PEG and MoS2-PEG/Au showed good chemical stability and demonstrated noninterference in the pattern of the cell nucleus, as well. Thus, our results suggest the possible application of these hybrid nanomaterials can be immensely explored for theranostic proposals in biomedicine.
dc.description.issuenumber12
dc.description.volume12
dc.identifier.doi10.3390/nano12122053
dc.identifier.issn2079-4991
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34356
dc.relation.ispartofNanomaterials
dc.rightsAcesso Aberto
dc.subject.otherlanguagebiocompatible
dc.subject.otherlanguagegold nanoparticles
dc.subject.otherlanguagehybrid nanostructures
dc.subject.otherlanguagemolybdenum disulfide
dc.subject.otherlanguagenanotechnology
dc.subject.otherlanguagePEGylated MoS2
dc.subject.otherlanguagetheranostic
dc.titleMultifunctional Hybrid MoS2-PEGylated/Au Nanostructures with Potential Theranostic Applications in Biomedicine
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-85131890136
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131890136&origin=inward
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