Pediatric dyslipidemia is associated with increased urinary ACE activity, blood pressure values, and carotidal-femoral pulse wave velocity

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dc.contributor.authorCruz N.A.N.
dc.contributor.authorde Oliveira L.C.G.
dc.contributor.authorFernandes F.B.
dc.contributor.authorZaniqueli D.A.
dc.contributor.authorOliosa P.R.
dc.contributor.authorMill J.G.
dc.contributor.authorCasarini D.E.
dc.date.accessioned2024-03-12T19:09:26Z
dc.date.available2024-03-12T19:09:26Z
dc.date.issued2023
dc.description.abstract© 2023, The Author(s), under exclusive licence to The Japanese Society of Hypertension.This study aimed to evaluate the enzymatic activity of the angiotensin-converting enzyme (ACE) in children and adolescents to investigate their relationship with dyslipidemia and other cardiometabolic alterations. Anthropometric measurements, blood pressure (BP), and fasting lipid concentrations were taken from 360 subjects. Categorization was done according to the levels of each lipoprotein (total cholesterol, triglycerides (TG), LDL-C, HDL-C, and non-HDL-C) into three groups: normolipidemic (NL), borderline (BL), and dyslipidemic (DL). Enzymatic activity in urine was measured using the substrates Z-FHL-OH and hippuryl-HL-OH (h-HL-OH) and the ACE activity ratio (Z-FHL-OH/h-HL-OH) was calculated. Dyslipidemic levels of HDL-C, TG, and LDL-C were observed in 23%, 9%, and 3% of the participants, respectively, and were more frequent in obese children (Chi-square, p < 0.001). ACE activity ratio was augmented in BL(HDL-C) when compared to NL(HDL-C) (5.06 vs. 2.39, p < 0.01), in DL(LDL-C) in comparison to BL(LDL-C) and NL(LDL-C) (8.7 vs. 1.8 vs. 3.0, p < 0.01), and in DL(non-HDL-C) than in BL(non-HDL-C) and in NL(non-HDL-C) (6.3 vs. 2.1 vs. 2.9, p = 0.02). The groups with impaired HDL-C and TG levels presented an increased diastolic BP percentile, and a higher systolic BP percentile was observed in BL(TG) and DL(TG). The carotidal-femoral pulse wave velocity (cfPWV) was higher in the groups with DL levels of TG and LDL-C than in NL groups. Hypertriglyceridemia was associated with higher cfPWV. No direct impact of the ACE activity on BP values was observed in this cohort, however, there was an association between hyperlipidemia and ACE upregulation which can trigger mechanisms driving to early onset of hypertension and cardiovascular disease. [Figure not available: see fulltext.]
dc.description.firstpage1558
dc.description.issuenumber6
dc.description.lastpage1569
dc.description.volume46
dc.identifier.doi10.1038/s41440-023-01240-y
dc.identifier.issn1348-4214
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34068
dc.relation.ispartofHypertension Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageAngiotensin-converting enzyme
dc.subject.otherlanguageBlood pressure
dc.subject.otherlanguageCarotidal-femoral pulse wave velocity
dc.subject.otherlanguagePediatric dyslipidemia
dc.titlePediatric dyslipidemia is associated with increased urinary ACE activity, blood pressure values, and carotidal-femoral pulse wave velocity
dc.typeArtigo
local.scopus.citations2
local.scopus.eid2-s2.0-85150655021
local.scopus.subjectAdolescent
local.scopus.subjectAngiotensins
local.scopus.subjectBlood Pressure
local.scopus.subjectChild
local.scopus.subjectCholesterol, HDL
local.scopus.subjectCholesterol, LDL
local.scopus.subjectDyslipidemias
local.scopus.subjectHumans
local.scopus.subjectPediatric Obesity
local.scopus.subjectPulse Wave Analysis
local.scopus.subjectTriglycerides
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150655021&origin=inward
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