Serum levels of magnesium in sudden cardiac deaths among people with schizophrenia: Hit or miss? Níveis séricos de magnésio em morte súbita entre pessoas com esquizofrenia: Erro ou acerto?

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dc.contributor.authorScorza F.A.
dc.contributor.authorde Albuquerque M.
dc.contributor.authorArida R.M.
dc.contributor.authorCysneiros R.M.
dc.date.accessioned2024-03-13T01:08:58Z
dc.date.available2024-03-13T01:08:58Z
dc.date.issued2012
dc.description.abstractSchizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to prevention. Although different mechanisms may be related, there are clear indications that cardiac abnormalities play a potential role. Some antipsychotics may be associated with cardiovascular adverse events, e.g., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. Magnesium (Mg) abnormalities may lead to various morphological and functional dysfunctions of the heart and low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is associated with detrimental effects on the heart and that antipsychotic-treated schizophrenia patients frequently affect the heart rate, possibly, these factors together must change the normal functioning of the heart and consequently being able to culminate in a catastrophic event.
dc.description.firstpage814
dc.description.issuenumber10
dc.description.lastpage816
dc.description.volume70
dc.identifier.doi10.1590/S0004-282X2012001000011
dc.identifier.issn1678-4227
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36859
dc.relation.ispartofArquivos de Neuro-Psiquiatria
dc.rightsAcesso Aberto
dc.subject.otherlanguageMagnesium
dc.subject.otherlanguageSchizophrenia
dc.subject.otherlanguageSudden death
dc.titleSerum levels of magnesium in sudden cardiac deaths among people with schizophrenia: Hit or miss? Níveis séricos de magnésio em morte súbita entre pessoas com esquizofrenia: Erro ou acerto?
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-84867852506
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867852506&origin=inward
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