Impaired interhemispheric interactions in patients with major depression

Página do item simplificado
dc.contributor.authorBajwa S.
dc.contributor.authorBermpohl F.
dc.contributor.authorRigonatti S.P.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorBoggio P.S.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:37:12Z
dc.date.available2024-03-13T01:37:12Z
dc.date.issued2008
dc.description.abstractPrevious studies have shown that patients with major depression have an interhemispheric imbalance between right and left prefrontal and motor cortex. We aimed to investigate the interhemispheric interactions in patients with major depression using repetitive transcranial magnetic stimulation (rTMS). Thirteen patients with major depression and 14 age-matched healthy subjects participated in this study. Corticospinal excitability before and after 1 Hz rTMS (applied to the left primary motor cortex) was assessed in the left and right motor cortex and these results were compared with those in healthy subjects. There was a significant difference in the interhemispheric effects between patients with depression and healthy subjects. In healthy subjects, 1 Hz rTMS significantly decreased corticospinal excitability in the stimulated, left hemisphere and increased it in the contralateral, right hemisphere. In depressed subjects, 1 Hz rTMS also decreased corticospinal excitability in the left hemisphere; however, it induced no significant changes in corticospinal excitability in the contralateral, right hemisphere. In addition, there was a significant correlation between the degree of interhemispheric modulation and the severity of the depression as indexed by the Beck Depression Inventory scores. Our findings showing a decreased interhemispheric modulation in patients with major depression are consistent with the notion that mood disorders are associated with slow interhemispheric switching mechanisms. Copyright © 2008 by Lippincott Williams & Wilkins.
dc.description.firstpage671
dc.description.issuenumber9
dc.description.lastpage677
dc.description.volume196
dc.identifier.doi10.1097/NMD.0b013e318183f86f
dc.identifier.issn0022-3018
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37501
dc.relation.ispartofJournal of Nervous and Mental Disease
dc.rightsAcesso Restrito
dc.subject.otherlanguageCorticospinal excitability
dc.subject.otherlanguageInterhemispheric modulation
dc.subject.otherlanguageMajor depression
dc.subject.otherlanguageTranscallosal inhibition
dc.subject.otherlanguageTranscranial magnetic stimulation
dc.titleImpaired interhemispheric interactions in patients with major depression
dc.typeArtigo
local.scopus.citations42
local.scopus.eid2-s2.0-52649175482
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=52649175482&origin=inward
Arquivos
Coleções
Artigos de periódico