Autonomic modulation of arterial pressure and heart rate variability in hypertensive diabetic rats

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dc.contributor.authorFarah V.D.M.A.
dc.contributor.authorDe Angelis K.
dc.contributor.authorJoaquim L.F.
dc.contributor.authorCandido G.O.
dc.contributor.authorBernardes N.
dc.contributor.authorFazan Jr. R.
dc.contributor.authorSchaan B.D'A.
dc.contributor.authorIrigoyen M.-C.
dc.date.accessioned2024-03-13T01:40:52Z
dc.date.available2024-03-13T01:40:52Z
dc.date.issued2007
dc.description.abstractOBJECTIVE: The aim of the present study was to evaluate the autonomic modulation of the cardiovascular system in streptozotocin (STZ)-induced diabetic spontaneously hypertensive rats (SHR), evaluating baroreflex sensitivity and arterial pressure and heart rate variability. METHODS: Male SHR were divided in control (SHR) and diabetic (SHR+DM, 5 days after STZ) groups. Arterial pressure (AP) and baroreflex sensitivity (evaluated by tachycardic and bradycardic responses to changes in AP) were monitored. Autoregressive spectral estimation was performed for systolic AP (SAP) and pulse interval (PI) with oscillatory components quantified as low (LF:0.2-0.6Hz) and high (HF:0.6-3.0Hz) frequency ranges. RESULTS: Mean AP and heart rate in SHR+DM (131±3 mmHg and 276±6 bpm) were lower than in SHR (160±7 mmHg and 330±8 bpm). Baroreflex bradycardia was lower in SHR+DM as compared to SHR (0.55±0.1 vs. 0.97±0.1 bpm/mmHg). Overall SAP variability in the time domain (standard deviation of beat-by-beat time series of SAP) was lower in SHR+DM (3.1±0.2 mmHg) than in SHR (5.7±0.6 mmHg). The standard deviation of the PI was similar between groups. Diabetes reduced the LF of SAP (3.3±0.8 vs. 28.7±7.6 mmHg2 in SHR), while HF of SAP were unchanged. The power of oscillatory components of PI did not differ between groups. CONCLUSIONS: These results show that the association of hypertension and diabetes causes an impairment of the peripheral cardiovascular sympathetic modulation that could be, at least in part, responsible for the reduction in AP levels. Moreover, this study demonstrates that diabetes might actually impair the reduced buffer function of the baroreceptors while reducing blood pressure.
dc.description.firstpage477
dc.description.issuenumber4
dc.description.lastpage482
dc.description.volume62
dc.identifier.doi10.1590/S1807-59322007000400015
dc.identifier.issn1807-5932
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37702
dc.relation.ispartofClinics
dc.rightsAcesso Aberto
dc.subject.otherlanguageBaroreflex sensitivity
dc.subject.otherlanguageCardiovascular function
dc.subject.otherlanguageDiabetes
dc.subject.otherlanguageHypertension
dc.subject.otherlanguageSpectral analysis
dc.titleAutonomic modulation of arterial pressure and heart rate variability in hypertensive diabetic rats
dc.typeArtigo
local.scopus.citations21
local.scopus.eid2-s2.0-34548796388
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34548796388&origin=inward
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