Assessment of psoriasis severity in Brazilian patients with chronic plaque psoriasis attending outpatient clinics: a multicenter, population-based cross-sectional study (APPISOT)

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dc.contributor.authorRomiti R.
dc.contributor.authorFabricio L.H.Z.
dc.contributor.authorSouza C.D.S.
dc.contributor.authorGalvao L.O.
dc.contributor.authorde Castro C.C.S.
dc.contributor.authorTerena A.C.
dc.contributor.authorCarneiro F.R.O.
dc.contributor.authorOyafuso L.K.M.
dc.contributor.authorCarneiro S.
dc.contributor.authorGontijo B.
dc.contributor.authorKobata C.M.
dc.contributor.authorde Oliveira M.D.F.P.
dc.contributor.authorCestari T.
dc.contributor.authorAntonio J.R.
dc.contributor.authorMartins G.A.
dc.contributor.authorMarques S.A.
dc.contributor.authorChaibub S.C.W.
dc.contributor.authorArruda A.C.B.B.
dc.contributor.authorFelix P.A.O.
dc.contributor.authorMagalhaes R.F.
dc.contributor.authorAbulafia L.A.
dc.contributor.authorFerreira K.A.
dc.contributor.authorMedeiros da Silva A.
dc.contributor.authorSilva B.L.
dc.contributor.authorSouza J.
dc.date.accessioned2024-03-12T23:56:14Z
dc.date.available2024-03-12T23:56:14Z
dc.date.issued2018
dc.description.abstract© 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.Purpose: Data on chronic plaque psoriasis severity and its potential clinical and lifestyle implications in the Brazilian population are limited. The primary aim of this study was to assess the clinical severity of plaque psoriasis in Brazil. Further objectives included evaluating potential associations between disease severity and demographic, lifestyle, and clinical characteristics, health-related quality of life (HRQOL), and work productivity. Materials and methods: This observational (non-interventional) cross-sectional study was conducted in 26 dermatologic clinics across 11 Brazilian states. Psoriasis severity was assessed using investigator judgment and Finlay’s Rule of Tens: a Psoriasis Area and Severity Index (PASI) score >10, a Body Surface Area (BSA) > 10%, or a Dermatology Life Quality Index (DLQI) score >10. Results: Among 1125 patients, 205 (18.2%) had moderate-to-severe disease. On multiple regression analyses, psoriasis severity was significantly (directly) associated with the presence of physical inactivity and comorbid pain, anxiety, and depression; and significantly (inversely) associated with HRQOL and work productivity. Limitations: Cross-sectional studies cannot assess temporal trends, and observational studies cannot conclusively determine causality or exclude biases and confounding due to unmeasured variables. Conclusions: Among Brazilian patients with moderate-to-severe psoriasis, disease severity had far-reaching adverse impacts on lifestyle, comorbidities, HRQOL, and work productivity.
dc.description.firstpage775
dc.description.issuenumber8
dc.description.lastpage785
dc.description.volume29
dc.identifier.doi10.1080/09546634.2018.1466023
dc.identifier.issn1471-1753
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35437
dc.relation.ispartofJournal of Dermatological Treatment
dc.rightsAcesso Restrito
dc.subject.otherlanguageEpidemiology
dc.subject.otherlanguagehealth-related quality of life
dc.subject.otherlanguagepain
dc.subject.otherlanguagepsoriasis
dc.subject.otherlanguageseverity
dc.subject.otherlanguageworker productivity
dc.titleAssessment of psoriasis severity in Brazilian patients with chronic plaque psoriasis attending outpatient clinics: a multicenter, population-based cross-sectional study (APPISOT)
dc.typeArtigo
local.scopus.citations12
local.scopus.eid2-s2.0-85048803480
local.scopus.subjectAdult
local.scopus.subjectAged
local.scopus.subjectAmbulatory Care Facilities
local.scopus.subjectBrazil
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectDepression
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectPsoriasis
local.scopus.subjectQuality of Life
local.scopus.subjectRegression Analysis
local.scopus.subjectSeverity of Illness Index
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048803480&origin=inward
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