Are there risk factors for acute renal failure in adult patients using deoxycholate amphotericin B?

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dc.contributor.authorTuon F.F.
dc.contributor.authorKoenig F.
dc.contributor.authorJacometto D.
dc.contributor.authorRocha J.L.
dc.date.accessioned2024-03-13T01:05:13Z
dc.date.available2024-03-13T01:05:13Z
dc.date.issued2013
dc.description.abstractBackground: Deoxycholate amphotericin B (DAB) is a nephrotoxic drug and the incidence of acute kidney injury (AKI) is high. Aims: The aim of this study was to describe the incidence of AKI in patients under DAB therapy and determine risk factor to predict the AKI. Methods: The data of this retrospective study included previously hospitalized patients treated with intravenous DAB for at least five days. Clinical and laboratorial data were evaluated and AKI was classified in stages using Acute Kidney Injury Network criteria. Univariated test followed by a multivariable analysis was performed to determine risk factor and Kaplan-Meier survival estimates were calculated to evaluate the role of AKI in the outcome. Results: One hundred six patients were included in the final analysis. AKI occurred in 51.9% and dialysis was necessary in 4.7%. The occurrence of AKI was not associated with any risk factor. The mortality of the patients was neither associated with AKI nor with dialysis. Other nephrotoxic drugs were not risk factors for AKI. Conclusions: The incidence of AKI in patients using DAB is high and we cannot predict the chance of AKI using clinical or laboratorial data. © 2012 Revista Iberoamericana de Micología.
dc.description.firstpage21
dc.description.issuenumber1
dc.description.lastpage24
dc.description.volume30
dc.identifier.doi10.1016/j.riam.2012.09.003
dc.identifier.issn1130-1406
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36646
dc.relation.ispartofRevista Iberoamericana de Micologia
dc.rightsAcesso Restrito
dc.subject.otherlanguageAcute kidney injury
dc.subject.otherlanguageAcute renal failure
dc.subject.otherlanguageAmphotericin B deoxycholate
dc.subject.otherlanguageCreatinine
dc.titleAre there risk factors for acute renal failure in adult patients using deoxycholate amphotericin B?
dc.typeArtigo
local.scopus.citations9
local.scopus.eid2-s2.0-84872805576
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872805576&origin=inward
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