MOLECULAR DEREPLICATION OF VOLATILE OILS FROM Saururus cernuus L. And EVALUATION OF ANTI-Trypanosoma cruzi ACTIVITY

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dc.contributor.authorBrito J.R.
dc.contributor.authorCosta-Silva T.A.
dc.contributor.authorLondero V.S.
dc.contributor.authorBaldim J.L.
dc.contributor.authorTempone A.G.
dc.contributor.authorFerreira E.A.
dc.contributor.authorLago J.H.G.
dc.date.accessioned2024-03-12T19:17:20Z
dc.date.available2024-03-12T19:17:20Z
dc.date.issued2022
dc.description.abstract© 2022 Sociedade Brasileira de Quimica. All rights reserved.The present study reports the molecular dereplication and the evaluation of anti-Trypanosoma cruzi activity of volatile oils from inflorescences, leaves, branches, and roots of Saururus cernuus L. (Saururaceae). Chemically, the oils showed the predominance of sesquiterpenes in inflorescences (64.04%) and branches (63.82%), with b-sesquiphellandrene (25.50%) and (E)-caryophyllene (22.40%) corresponding to the main constituents of each oil. Furthermore, it was possible to detect safrole as the most predominant compound in the leaves oil (49.09%). On the other hand, the oil from roots was mainly composed by monoterpenes (84.60%), with limonene in higher concentration (38.41%), followed by α-pinene (20.19%), and camphene (14.71%). The oils from inflorescences and branches displayed higher antitrypanosomal potency with EC50 values of 7.1 and 8.8 μg mL-1, respectively, followed by the oils from the roots and inflorescences, with EC50 values of 17.3 and 30.4 μg mL-1, respectively. Additionally, branches and inflorescences oils displayed no toxicity in mammalian NCTC cells (CC50 > 200 μg mL-1). Using two PLS-DA methods, it was possible to suggest that the anti-T. cruzi activity of the tested oils could be associated with the presence of b-sesquiphellandrene, safrole, b-elemene, and α-zingiberene whereas threo-austrobailignan-5, b-sesquiphellandrene, α-humulene, germacrene D, and bicyclogermacrene play a role in the cytotoxicity against NCTC cells.
dc.description.firstpage159
dc.description.issuenumber2
dc.description.lastpage164
dc.description.volume45
dc.identifier.doi10.21577/0100-4042.20170811
dc.identifier.issn1678-7064
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34491
dc.relation.ispartofQuimica Nova
dc.rightsAcesso Aberto
dc.subject.otherlanguagesafrol
dc.subject.otherlanguageSaururus cernuus
dc.subject.otherlanguageterpenes
dc.subject.otherlanguageTrypanosoma cruzi
dc.subject.otherlanguagevolatile oils
dc.titleMOLECULAR DEREPLICATION OF VOLATILE OILS FROM Saururus cernuus L. And EVALUATION OF ANTI-Trypanosoma cruzi ACTIVITY
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-85131937676
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85131937676&origin=inward
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