Prognosis of patients with systemic lupus erythematosus and discoid lesions Prognóstico de pacientes com lúpus eritematoso sistêmico e lesões discóides

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dc.contributor.authorSkare T.L.
dc.contributor.authorStadler B.
dc.contributor.authorWeingraber E.
dc.contributor.authorDe Paula D.F.
dc.date.accessioned2024-03-13T01:03:55Z
dc.date.available2024-03-13T01:03:55Z
dc.date.issued2013
dc.description.abstractBACKGROUND: It has been observed that patients with systemic lupus erythematosus and discoid lesions have a milder systemic disease. OBJECTIVE: To compare the clinical, demographic and autoantibody profile of systemic lupus erythematosus patients with and without discoid lesions. METHODS: We carried out a retrospective study involving 288 systemic lupus erythematosus patients who met at least four classification criteria of the American College of Rheumatology for systemic lupus erythematosus, comparing the clinical, serological and demographic factors between patients with and without discoid manifestations. RESULTS: Of the 288 patients, 13.8% had discoid lesions. Univariate analysis found no differences in the prevalence of malar rash, photosensitivity, arthritis, serositis, leukopenia, lymphopenia and hemolytic anemia or anemia of the central nervous system (p = ns). Renal lesions were more common in those without discoid lesions (p =0.016), and hemolysis (p<0.0001) was more common in those with discoid lesions. Regarding the profile of autoantibodies, only the anti-RNP antibody was more common in those with discoid events (p =0.04). In a logistic regression study, only the renal lesions and anti-RNP maintained their associations with discoid manifestations. CONCLUSION: Patients with lesions of systemic lupus erythematosus and discoid lesions have lower prevalence of renal involvement and a greater presence of anti RNP. © 2013 by Anais Brasileiros de Dermatologia.
dc.description.firstpage755
dc.description.issuenumber5
dc.description.lastpage758
dc.description.volume88
dc.identifier.doi10.1590/abd1806-4841.20132042
dc.identifier.issn0365-0596
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36573
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageCutaneous
dc.subject.otherlanguageDiscoid
dc.subject.otherlanguageGlomerulonephritis
dc.subject.otherlanguageLupus erythematosus
dc.subject.otherlanguageSystemic
dc.titlePrognosis of patients with systemic lupus erythematosus and discoid lesions Prognóstico de pacientes com lúpus eritematoso sistêmico e lesões discóides
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-84891847393
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891847393&origin=inward
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