O efeito do extrato de própolis verde no prejuízo cognitivo induzido pelo cortisol em camundongos C57
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Tipo
TCC
Data de publicação
2023-12
Periódico
Citações (Scopus)
Autores
Machado, Stefany Kolndorfer
Orientador
Ribeiro, Miriam Oliveira
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Resumo
A ansiedade é uma resposta natural do organismo a situações percebidas como ameaçadoras ou desafiadoras. No entanto, quando a ansiedade se torna excessiva, persistente e interfere nas atividades diárias, pode ser considerada patológica. A ansiedade patológica pode afetar a cognição devido ao aumento de cortisol, prejudicando a concentração, memória, tomada de decisões e sono que, por sua vez, contribui para a deterioração da cognição. Considerando a ansiedade e estresse do cotidiano, é importante buscar estratégias saudáveis para lidar com a ansiedade. O extrato de própolis verde é uma substância natural produzida por abelhas a partir de resinas de plantas e contém flavonoides que possuem propriedades ansiolíticas. Sendo assim, nós levantamos a hipótese de que o uso de própolis verde pode reverter ou mitigar as alterações cognitivas causadas pelo excesso de cortisol. Dessa maneira, o objetivo deste estudo foi investigar os efeitos da administração de própolis verde em um modelo de estresse por administração de cortisona na água de beber. Para tanto, camundongos C57 foram submetidos a tratamento com dexametasona (3mg/Kg) e Própolis verde (125 mg/Kg) diariamente na água de beber por 15 a 20 dias. Ao final do tratamento, foram submetidos a teste de reconhecimento social para avaliar a memória declarativa e sociabilidade dos animais. Os nossos resultados mostram que o tratamento com Extrato de Própolis Verde foi capaz de reverter os prejuízos induzidos pela dexametasona. Esses dados sugerem que o Própolis verde exibe potencial terapêutico para reduzir os efeitos deletérios sobre a memória induzidos pelo estresse crônico.
Anxiety is a natural response of the body to situations perceived as threatening or challenging. However, when anxiety becomes excessive, persistent and interferes with daily activities, it can be considered pathological. Pathological anxiety can affect cognition due to an increase in cortisol, impairing concentration, memory, decision-making and sleep, which in turn contributes to the deterioration of cognition. Considering the anxiety and stress of everyday life, it is important to look for healthy strategies to deal with anxiety. Green propolis extract is a natural substance produced by bees from plant resins and contains flavonoids have anxiolytic properties. Therefore, we hypothesized that the use of green propolis could reverse or mitigate the cognitive alterations caused by excess cortisol. Therefore, the aim of this study was to investigate the effects of administering green propolis in a stress model by administering cortisone in drinking water. To this end, C57 mice were treated with dexamethasone (3mg/Kg) and green propolis (125 mg/Kg) daily in their drinking water for 15 to 20 days. At the end of the treatment, they underwent a social recognition test to assess the animals' declarative memory and sociability. Our results show that treatment with Green Propolis Extract was able to reverse the damage induced by dexamethasone. These data suggest that green propolis has therapeutic potential for reducing the deleterious effects on memory induced by chronic stress.
Anxiety is a natural response of the body to situations perceived as threatening or challenging. However, when anxiety becomes excessive, persistent and interferes with daily activities, it can be considered pathological. Pathological anxiety can affect cognition due to an increase in cortisol, impairing concentration, memory, decision-making and sleep, which in turn contributes to the deterioration of cognition. Considering the anxiety and stress of everyday life, it is important to look for healthy strategies to deal with anxiety. Green propolis extract is a natural substance produced by bees from plant resins and contains flavonoids have anxiolytic properties. Therefore, we hypothesized that the use of green propolis could reverse or mitigate the cognitive alterations caused by excess cortisol. Therefore, the aim of this study was to investigate the effects of administering green propolis in a stress model by administering cortisone in drinking water. To this end, C57 mice were treated with dexamethasone (3mg/Kg) and green propolis (125 mg/Kg) daily in their drinking water for 15 to 20 days. At the end of the treatment, they underwent a social recognition test to assess the animals' declarative memory and sociability. Our results show that treatment with Green Propolis Extract was able to reverse the damage induced by dexamethasone. These data suggest that green propolis has therapeutic potential for reducing the deleterious effects on memory induced by chronic stress.
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Palavras-chave
memória , estresse crônico , cortisol , sociabilidade , chronic stress , memory , cortisol , sociability