Effects of perinatal picrotoxin and sexual experience on heterosexual and homosexual behavior in male rats

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dc.contributor.authorTeodorov E.
dc.contributor.authorSalzgeber S.A.
dc.contributor.authorFelicio L.F.
dc.contributor.authorVarolli F.M.F.
dc.contributor.authorBernardi M.M.
dc.date.accessioned2024-03-13T01:46:29Z
dc.date.available2024-03-13T01:46:29Z
dc.date.issued2002
dc.description.abstractThe effects of perinatal picrotoxin (0.75 mg/kg) on heterosexual and homosexual behavior of male rats, sexually experienced or not, were studied. The following data were obtained: (1) at birth, body weight and anogenital distance were not modified by the treatment; (2) during lactation, both treatment and sex interfered with body weight as well as in adult age; (3) as experimental animals were trained, the heterosexual behavior was improved; (4) picrotoxin treatment reduced lordotic response of homosexual behavior in inexperienced male rats and (5) the heterosexual experience with female rats inhibited homosexual behavior of both experimental and control animals. These results suggest that perinatal maternal picrotoxin exposure improved heterosexual behavior in male rats and the sexual experience reveals this effect. In addition, picrotoxin did not induce feminization in experimental inexperienced rats. Finally, the sexual experience per se promotes changes in brain regions related to male behavioral and sexual aspects. © 2002 Published by Elsevier Science Inc.
dc.description.firstpage235
dc.description.issuenumber2
dc.description.lastpage245
dc.description.volume24
dc.identifier.doi10.1016/S0892-0362(01)00213-6
dc.identifier.issn0892-0362
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/38010
dc.relation.ispartofNeurotoxicology and Teratology
dc.rightsAcesso Restrito
dc.subject.otherlanguageDopamine
dc.subject.otherlanguageGABA
dc.subject.otherlanguageHeterosexual behavior
dc.subject.otherlanguageHomosexual behavior
dc.subject.otherlanguageLordosis
dc.subject.otherlanguagePerinatal picrotoxin
dc.titleEffects of perinatal picrotoxin and sexual experience on heterosexual and homosexual behavior in male rats
dc.typeArtigo
local.scopus.citations14
local.scopus.eid2-s2.0-0036205549
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0036205549&origin=inward
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