A theoretical model for estimating the margination constant of leukocytes
| dc.contributor.author | Iadocicco K. | |
| dc.contributor.author | Monteiro L.H.A. | |
| dc.contributor.author | Chaui-Berlinck J.G. | |
| dc.date.accessioned | 2024-03-13T01:46:31Z | |
| dc.date.available | 2024-03-13T01:46:31Z | |
| dc.date.issued | 2002 | |
| dc.description.abstract | Background: Blood leukocytes constitute two interchangeable sub-populations, the marginated and circulating pools. These two sub-compartments are found in normal conditions and are potentially affected by non-normal situations, either pathological or physiological. The dynamics between the compartments is governed by rate constants of margination (M) and return to circulation (R). Therefore, estimates of M and R may prove of great importance to a deeper understanding of many conditions. However, there has been a lack of formalism in order to approach such estimates. The few attempts to furnish an estimation of M and R neither rely on clearly stated models that precisely say which rate constant is under estimation nor recognize which factors may influence the estimation. Results: The returning of the blood pools to a steady-state value after a perturbation (e.g., epinephrine injection) was modeled by a second-order differential equation. This equation has two eigenvalues, related to a fast- and to a slow-component of the dynamics. The model makes it possible to identify that these components are partitioned into three constants: R, M and SB; where SB is a time-invariant exit to tissues rate constant. Three examples of the computations are worked and a tentative estimation of R for mouse monocytes is presented. Conclusions: This study establishes a firm theoretical basis for the estimation of the rate constants of the dynamics between the blood sub-compartments of white cells. It shows, for the first time, that the estimation must also take into account the exit to tissues rate constant, SB. | |
| dc.description.firstpage | 1 | |
| dc.description.lastpage | 8 | |
| dc.description.volume | 2 | |
| dc.identifier.doi | 10.1186/1472-6793-2-1 | |
| dc.identifier.issn | 1472-6793 | |
| dc.identifier.uri | https://dspace.mackenzie.br/handle/10899/38012 | |
| dc.relation.ispartof | BMC Physiology | |
| dc.rights | Acesso Aberto | |
| dc.title | A theoretical model for estimating the margination constant of leukocytes | |
| dc.type | Artigo | |
| local.scopus.citations | 9 | |
| local.scopus.eid | 2-s2.0-3342960550 | |
| local.scopus.updated | 2024-05-01 | |
| local.scopus.url | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=3342960550&origin=inward |