Green tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice

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dc.contributor.authorSousa-Filho C.P.B.
dc.contributor.authorFaria H.O.F.
dc.contributor.authorEsposito J.C.
dc.contributor.authorMelo A.
dc.contributor.authorRibeiro M.O.
dc.contributor.authorOtton R.
dc.date.accessioned2024-03-12T23:47:00Z
dc.date.available2024-03-12T23:47:00Z
dc.date.issued2020
dc.description.abstract© 2020 Elsevier LtdOur goal was to establish the requirement of β3 adrenoceptor (β3Adr) for green tea (GT) effects on the energy metabolism of obese mice. This study was carried out in wild-type (WT) and β3Adr knockout (KO) male mice fed with a standard diet or a high-fat diet (HFD/16 weeks) treated or not with GT (0.5 g/kg of body weight (BW)/12 weeks). GT-treatment attenuated final BW, BW gain, and adiposity index increased by HFD, improving insulin resistance (IR) and FGF21 level, without changing the food intake of WT mice. GT-treatment of β3AdrKO mice attenuated only IR, denoting GT-effects independent of β3Adr. We observed increased lipolysis accompanied by decreased adipocyte size in white adipose tissue (WAT) as well as browning of the subcutaneous WAT induced by GT in a way dependent on β3Adr. In brown adipose tissue (BAT) mRNA levels of lipolytic/oxidative genes, including β3Adr/Ucp1 and energy expenditure (EE) was increased by GT dependent on β3Adr. GT-treatment increased adiponectin independent of β3Adr. Also, independent of β3Adr pathway GT promoted an increase in β2Adr/Ucp1 mRNA levels and EE in BAT whereas; in the liver, GT has a dual role in increasing lipid synthesis and oxidation. These data lead us to suggest that GT uses β3Adr pathway activation to achieve some of its beneficial health effects.
dc.description.volume159
dc.identifier.doi10.1016/j.phrs.2020.104956
dc.identifier.issn1096-1186
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34926
dc.relation.ispartofPharmacological Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageBrown adipose tissue
dc.subject.otherlanguageCatechins
dc.subject.otherlanguageEnergy expenditure
dc.subject.otherlanguageObesity
dc.subject.otherlanguageβ3-Adrenergic receptor
dc.titleGreen tea improves the metabolism of peripheral tissues in β3-adrenergic receptor-knockout mice
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-85086601236
local.scopus.subjectAdiponectin
local.scopus.subjectAdipose Tissue, Brown
local.scopus.subjectAdipose Tissue, White
local.scopus.subjectAdiposity
local.scopus.subjectAnimals
local.scopus.subjectAnti-Obesity Agents
local.scopus.subjectCamellia sinensis
local.scopus.subjectDiet, High-Fat
local.scopus.subjectDisease Models, Animal
local.scopus.subjectEnergy Metabolism
local.scopus.subjectLipolysis
local.scopus.subjectMale
local.scopus.subjectMice, Knockout
local.scopus.subjectObesity
local.scopus.subjectPlant Extracts
local.scopus.subjectReceptors, Adrenergic, beta-3
local.scopus.subjectUncoupling Protein 1
local.scopus.subjectWeight Gain
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85086601236&origin=inward
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