Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network

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dc.contributor.authorFerreira A.K.
dc.contributor.authorDe-Sa-Junior P.L.
dc.contributor.authorPasqualoto K.F.M.
dc.contributor.authorDe Azevedo R.A.
dc.contributor.authorCamara D.A.D.
dc.contributor.authorCosta A.S.
dc.contributor.authorFigueiredo C.R.
dc.contributor.authorMatsuo A.L.
dc.contributor.authorMassaoka M.H.
dc.contributor.authorAuada A.V.V.
dc.contributor.authorLebrun I.
dc.contributor.authorDamiao M.C.F.C.B.
dc.contributor.authorTavares M.T.
dc.contributor.authorMagri F.M.M.
dc.contributor.authorKerkis I.
dc.contributor.authorParise Filho R.
dc.date.accessioned2024-03-13T01:00:38Z
dc.date.available2024-03-13T01:00:38Z
dc.date.issued2014
dc.description.abstractBreast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. The use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Here, we have demonstrated for the first time that dillapiole has broad cytotoxic effects against a variety tumor cells. For instance, we found that it can act as a pro-oxidant compound through the induction of reactive oxygen species (ROS) release in MDA-MB-231 cells. We also demonstrated that dillapiole exhibits anti-proliferative properties, arresting cells at the G0/G1 phase and its antimigration effects can be associated with the disruption of actin filaments, which in turn can prevent tumor cell proliferation. Molecular modeling studies corroborated the biological findings and suggested that dillapiole may present a good pharmacokinetic profile, mainly because its hydrophobic character, which can facilitate its diffusion through tumor cell membranes. All these findings support the fact that dillapiole is a promising anticancer agent. © 2013 Elsevier Masson SAS. All rights reserved.
dc.description.firstpage195
dc.description.issuenumber1
dc.description.lastpage207
dc.description.volume99
dc.identifier.doi10.1016/j.biochi.2013.12.008
dc.identifier.issn0300-9084
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36390
dc.relation.ispartofBiochimie
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntitumoral
dc.subject.otherlanguageApoptosis
dc.subject.otherlanguageCell cycle
dc.subject.otherlanguageDillapiole
dc.subject.otherlanguageMolecular modeling
dc.subject.otherlanguagePiper aduncum
dc.subject.otherlanguageROS
dc.titleCytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network
dc.typeArtigo
local.scopus.citations28
local.scopus.eid2-s2.0-84894033242
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84894033242&origin=inward
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