Chronic cachaça consumption affects the structure of tibial bone by decreasing bone density and density of mature collagen fibers in middle-aged Wistar rats

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dc.contributor.authorRenato Romero J.
dc.contributor.authorKrause Neto W.
dc.contributor.authorSabbag da Silva A.
dc.contributor.authorLuiz dos Santos E.
dc.contributor.authorAurelio Added M.
dc.contributor.authorPianca E.
dc.contributor.authorFlorencio Gama E.
dc.contributor.authorRodrigues de Souza R.
dc.date.accessioned2024-03-12T23:50:44Z
dc.date.available2024-03-12T23:50:44Z
dc.date.issued2020
dc.description.abstract© 2018 Informa UK Limited, trading as Taylor & Francis Group.Several studies have demonstrated that alcohol consumption can decrease bone density and alter its structure. However, most of the studies did not investigate the effects of specific alcoholic beverages. This study determined the effects of chronic consumption of cachaça (a Brazilian beverage containing alcohol) on body weight (BW), tibia bone density and on the tibia collagen density in middle-aged Wistar rats. Rats with 9 months old were submitted for 100 days, to a liquid diet of cachaça diluted in water with a progressive and controlled concentration (10°GL, 15°GL, 20°GL, 25°GL, and 30°GL). Chronic cachaça intake produced a significant decrease in BW and altered bone remodeling, decreasing trabecular bone density. In chronic cachaça-treated group (CT), the production of collagen fibers in bone tissue has predominantly green birefringence. It appears that they are immature fibers that do not exist in the control group, in which there are standard predominantly yellowish mature fibers. In conclusion, chronic cachaça consumption affects the structure of the tibial bone of middle-aged rats by decreasing the bone density and reducing the density of mature collagen fibers.
dc.description.firstpage251
dc.description.issuenumber4
dc.description.lastpage256
dc.description.volume23
dc.identifier.doi10.1080/13685538.2018.1477932
dc.identifier.issn1473-0790
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35137
dc.relation.ispartofAging Male
dc.rightsAcesso Restrito
dc.subject.otherlanguageAlcoholism
dc.subject.otherlanguagebone remodeling
dc.subject.otherlanguagecollagen fibers
dc.subject.otherlanguagetibia
dc.titleChronic cachaça consumption affects the structure of tibial bone by decreasing bone density and density of mature collagen fibers in middle-aged Wistar rats
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85047915938
local.scopus.subjectAlcoholic Beverages
local.scopus.subjectAnimals
local.scopus.subjectBody Weight
local.scopus.subjectBone Density
local.scopus.subjectBone Remodeling
local.scopus.subjectCollagen
local.scopus.subjectEthanol
local.scopus.subjectRandom Allocation
local.scopus.subjectRats
local.scopus.subjectRats, Wistar
local.scopus.subjectTibia
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85047915938&origin=inward
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