Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats

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dc.contributor.authorMostarda C.
dc.contributor.authorMoraes-Silva I.C.
dc.contributor.authorSalemi V.M.C.
dc.contributor.authorMachi J.F.
dc.contributor.authorRodrigues B.
dc.contributor.authorDe Angelis K.
dc.contributor.authorFarah V.M.A.
dc.contributor.authorIrigoyen M.C.
dc.date.accessioned2024-03-13T01:07:50Z
dc.date.available2024-03-13T01:07:50Z
dc.date.issued2012
dc.description.abstractObjective: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. Methods: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p<0.05. Results: Fructose overload induced a metabolic syndrome state, as confirmed by insulin resistance (F: 3.6 ± 0.2 vs. C: 4.5 ± 0.2 mg/dl/min), hypertension (mean blood pressure, F: 118 ± 3 vs. C: 104 ± 4 mmHg) and obesity (F: 0.31±0.001 vs. C: 0.29 ± 0.001 g/mm). Interestingly, fructose overload rats also exhibited diastolic dysfunction. Exercise training performed during the period of high fructose intake eliminated all of these derangements. The improvements in metabolic parameters were correlated with the maintenance of diastolic function. Conclusion: The role of exercise training in the prevention of metabolic and hemodynamic parameter alterations is of great importance in decreasing the cardiac morbidity and mortality related to metabolic syndrome. © 2012 CLINICS.
dc.description.firstpage815
dc.description.issuenumber7
dc.description.lastpage820
dc.description.volume67
dc.identifier.doi10.6061/clinics/2012(07)18
dc.identifier.issn1807-5932
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36795
dc.relation.ispartofClinics
dc.rightsAcesso Aberto
dc.subject.otherlanguageCardiac hypertrophy
dc.subject.otherlanguageDiastolic function
dc.subject.otherlanguageExercise Training
dc.subject.otherlanguageInsulin resistance
dc.subject.otherlanguageMetabolic Syndrome
dc.titleExercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
dc.typeArtigo
local.scopus.citations27
local.scopus.eid2-s2.0-84867088686
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84867088686&origin=inward
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