Lipid profile and anti-tnf-α use Perfil lipíacute;dico e uso de anti-TNF-α

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dc.contributor.authorFilho A.C.F.
dc.contributor.authordos Santos L.P.
dc.contributor.authorSilva M.B.
dc.contributor.authorSkare T.L.
dc.date.accessioned2024-03-13T01:05:51Z
dc.date.available2024-03-13T01:05:51Z
dc.date.issued2013
dc.description.abstractThe use of anti-TNF-α has been associated with several changes in lipid profile, although some study results are confl icting. The knowledge of this fact is of great importance when one observes at the association between rheumatic diseases and accelerated atherogenesis. The aim of this analysis was search for changes in lipid profile in anti TNF-α users in the population of Southern Brazil and its association with duration of use, indications, patient gender and type of anti-TNF. For this purpose, we studied the profiles of total cholesterol (TC), HDL cholesterol (HDLc), LDL cholesterol (LDLc), atherogenic index (ATI) and triglycerides (TGs) of 58 patients (42 with rheumatoid arthritis and 16 with spondyloarthritis) before and after using this drug for a median of 16.0 months. There were no changes in the levels of TC, HDLc, LDLc and ATI (P = NS). However, there was a significant increase in TG levels (P = 0.03). The median difference between first and second TG measurements was 16 mg/dL and this increase was not associated with gender, time of use, use indication or type of anti TNF-α (P = NS). It was concluded that the use of anti TNF-α is associated with increased values of TG. © 2013 Elsevier Editora Ltda.
dc.description.firstpage444
dc.description.issuenumber5
dc.description.lastpage447
dc.description.volume53
dc.identifier.doi10.1590/s0482-50042013000500013
dc.identifier.issn0482-5004
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36682
dc.relation.ispartofRevista Brasileira de Reumatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageAnti-TNF-alfa
dc.subject.otherlanguageAtherogenesis
dc.subject.otherlanguageRheumatoid arthritis
dc.subject.otherlanguageSpondiloarthritis
dc.titleLipid profile and anti-tnf-α use Perfil lipíacute;dico e uso de anti-TNF-α
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-84891701328
local.scopus.subjectArthritis, Rheumatoid
local.scopus.subjectCholesterol
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMiddle Aged
local.scopus.subjectRetrospective Studies
local.scopus.subjectSpondylarthropathies
local.scopus.subjectTriglycerides
local.scopus.subjectTumor Necrosis Factor-alpha
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84891701328&origin=inward
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