Emotional reactivity to valence-loaded stimuli are related to treatment response of neurocognitive therapy

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dc.contributor.authorVanderhasselt M.-A.
dc.contributor.authorDe Raedt R.
dc.contributor.authorNamur V.
dc.contributor.authorValiengo L.C.L.
dc.contributor.authorLotufo P.A.
dc.contributor.authorBensenor I.M.
dc.contributor.authorBaeken C.
dc.contributor.authorBoggio P.S.
dc.contributor.authorBrunoni A.R.
dc.date.accessioned2024-03-13T00:54:04Z
dc.date.available2024-03-13T00:54:04Z
dc.date.issued2016
dc.description.abstract© 2015 Elsevier B.V. All rights reserved.Emotional Context Insensitivity (ECI) is a psychological feature observed in depressed patients characterized by a decreased emotional reactivity when presented to positive- and negative valence-loaded stimuli. Given that fronto-cingulate-limbic circuits are implicated in abnormal reactivity to valence-loaded stimuli, neurocognitive treatments engaging the prefrontal cortex may be able to modulate this emotional blunting observed in MDD. Therefore, our goal was to evaluate emotional reactivity in depressed patients before and after a combination of neurocognitive interventions that engage the prefrontal cortex (cognitive control training and/or transcranial direct current stimulation). In line with the premises of the ECI framework, before the start of the antidepressant intervention, patients showed blunted emotional reactivity after exposure to negative valence-loaded stimuli. This emotional reactivity pattern changed after 9 sessions of the intervention: positive affect decreased and negative affect increased after watching a series of negative valence-loaded stimuli (i.e. images). Interestingly, higher emotional reactivity (as indexed by a larger increase in negative affect after watching the valence-loaded stimuli) at baseline predicted reductions in depression symptoms after the intervention. On the other hand, higher emotional reactivity (as indexed by a decrease in positive affect) after the intervention was marginally associated with reductions in depression symptoms. To conclude, emotional reactivity increased after the neurocognitive antidepressant intervention and it was directly associated to the degree of depression improvement.
dc.description.firstpage443
dc.description.lastpage449
dc.description.volume190
dc.identifier.doi10.1016/j.jad.2015.10.022
dc.identifier.issn1573-2517
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36020
dc.relation.ispartofJournal of Affective Disorders
dc.rightsAcesso Restrito
dc.subject.otherlanguageDepressive symptoms
dc.subject.otherlanguageEmotional Context Insensitivity
dc.subject.otherlanguageEmotional reactivity
dc.subject.otherlanguageNeurocognitive intervention
dc.subject.otherlanguagePositive and negative affect
dc.titleEmotional reactivity to valence-loaded stimuli are related to treatment response of neurocognitive therapy
dc.typeArtigo
local.scopus.citations7
local.scopus.eid2-s2.0-84946592919
local.scopus.subjectAdult
local.scopus.subjectAntidepressive Agents
local.scopus.subjectCognitive Therapy
local.scopus.subjectCombined Modality Therapy
local.scopus.subjectDepressive Disorder, Major
local.scopus.subjectEmotions
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectPhotic Stimulation
local.scopus.subjectPrefrontal Cortex
local.scopus.subjectTranscranial Direct Current Stimulation
local.scopus.subjectYoung Adult
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84946592919&origin=inward
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