Evaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella

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dc.contributor.authorZalewski C.A.
dc.contributor.authorPassero L.F.D.
dc.contributor.authorMelo A.S.R.B.
dc.contributor.authorCorbett C.E.P.
dc.contributor.authorLaurenti M.D.
dc.contributor.authorToyama M.H.
dc.contributor.authorToyama D.O.
dc.contributor.authorRomoff P.
dc.contributor.authorFavero O.A.
dc.contributor.authorLago J.H.G.
dc.date.accessioned2024-03-13T01:11:15Z
dc.date.available2024-03-13T01:11:15Z
dc.date.issued2011
dc.description.abstractContext: Species of Baccharis exhibit antibiotic, antiseptic, and wound-healing properties, and have been used in the traditional medicine of South America for the treatment of inflammation, headaches, diabetes, and hepatobiliary disorders. Objective: To investigate the anti-inflammatory activity of organic phases from EtOH extract of the aerial parts of Baccharis uncinella DC (Asteraceae). Materials and methods: The crude EtOH extract from the aerial parts of B. uncinella was subjected to partition procedures and the corresponding CH2Cl2 and EtOAc phases were subjected to several chromatographic separation procedures. Thus, these phases and their purified compounds were assayed for evaluation of anti-inflammatory activity. Results: The CH2Cl2 phase from EtOH extract from B. uncinella contained two triterpenoids (oleanolic and ursolic acids) and one flavonoid (pectolinaringenin), whereas the respective EtOAc phase showed to be composed mainly by two phenylpropanoid derivatives (caffeic and ferulic acids). The CH2Cl2 and EtOAc phases as well as their isolated compounds exhibited anti-inflammatory effects against inflammatory reactions induced by phospholipase A2 (from Crotalus durissus terrificus venom) and by carrageenan. Discussion and conclusion: The results suggested that the components obtained from partition phases of EtOH extract of B. uncinella could represent lead molecules for the development of anti-inflammatory agents. Additionally, the results confirmed the use of Baccharis genus in the traditional medicine of South America for the treatment of inflammation and other heath disorders. To date, the present work describes for the first time the anti-inflammatory effects of compounds isolated from B. uncinella. © 2011 Informa Healthcare USA, Inc.
dc.description.firstpage602
dc.description.issuenumber6
dc.description.lastpage607
dc.description.volume49
dc.identifier.doi10.3109/13880209.2010.537828
dc.identifier.issn1388-0209
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36986
dc.relation.ispartofPharmaceutical Biology
dc.rightsAcesso Aberto
dc.subject.otherlanguageanti-inflammatory
dc.subject.otherlanguagephenolic compounds
dc.subject.otherlanguageSecretory phospholipase A2 (sPLA2)
dc.subject.otherlanguagetriterpenes
dc.titleEvaluation of anti-inflammatory activity of derivatives from aerial parts of Baccharis uncinella
dc.typeArtigo
local.scopus.citations20
local.scopus.eid2-s2.0-79955816755
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=79955816755&origin=inward
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