Acute toxicity of psilocybe cubensis (Ear.) Sing., Strophariaceae, aqueous extract in mice Toxicidade aguda do extrato aquoso de Psilocybe cubensis em camundongos

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dc.contributor.authorKirsten T.B.
dc.contributor.authorBernardi M.M.
dc.date.accessioned2024-03-13T01:32:45Z
dc.date.available2024-03-13T01:32:45Z
dc.date.issued2010
dc.description.abstractPsilocybe cubensis (Ear.) Sing., Strophariaceae, is a hallucinogen mushroom that has been used since the old times by humans, causing several psychotic effects. P. cubensis contains two tryptamine derivates: psilocybin and psilocin, agonists of the 5-HT2 receptor (serotonin). The main objective of this study was to investigate the acute toxicity effects of P. cubensis aqueous extract(PCAE) administration in mice. Male and female adult Swiss mice received PCAE 0.1 mL/10 g i.p., and were observed individually, directly in a glass box and in an open-field. In relation to the data of the control group, PCAE-treated animals presented: an increased gnawing, appearance of wet-dog shakes and a decreased locomotion and rearing frequencies after 29-38 min. Also a clear gender difference was detected, being female mice more sensible to the PCAE than males. It was suggested that PCAE administration produced specific effects on mice behaviors, characteristic of drugs which interfere on central serotonergic and dopaminergic systems. Finally, the observational methods here employed were efficient to evaluate the toxic effects of the extract.
dc.description.firstpage397
dc.description.issuenumber3
dc.description.lastpage402
dc.description.volume20
dc.identifier.doi10.1590/S0102-695X2010000300017
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37252
dc.relation.ispartofRevista Brasileira de Farmacognosia
dc.rightsAcesso Aberto
dc.subject.otherlanguageBehavior
dc.subject.otherlanguageMice
dc.subject.otherlanguagePsilocin
dc.subject.otherlanguagePsilocybe cubensis
dc.subject.otherlanguagePsilocybin
dc.subject.otherlanguageSerotonin
dc.titleAcute toxicity of psilocybe cubensis (Ear.) Sing., Strophariaceae, aqueous extract in mice Toxicidade aguda do extrato aquoso de Psilocybe cubensis em camundongos
dc.typeArtigo
local.scopus.citations5
local.scopus.eid2-s2.0-77957584118
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77957584118&origin=inward
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