Which lesions are at higher risk of developing colorectal carcinomas: Superficially elevated serrated lesions or depressed lesions? QUAIS LESÕES APRESENTAM MAIOR RISCO DE EVOLUÇÃO PARA CARCINOMAS COLORRETAIS: AS SERRILHADAS SUPERFICIALMENTE ELEVADAS OU AS DEPRIMIDAS?

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dc.contributor.authorParada A.A.
dc.contributor.authorVenco F.E.
dc.contributor.authorVarca-Neto M.R.
dc.contributor.authorIbrahim R.E.
dc.contributor.authorPoletti P.B.
dc.contributor.authorBrito H.P.
dc.contributor.authorDe Fatima Sare H.
dc.contributor.authorMalafaia O.
dc.date.accessioned2024-10-01T06:17:25Z
dc.date.available2024-10-01T06:17:25Z
dc.date.issued2022
dc.description.abstract© 2022, Colegio Brasileiro de Cirurgia Digestiva. All rights reserved.BACKGROUND: There are lesions that are still being missed in colonoscopy. Many of those could be superficially elevated serrated lesions or depressed ones. AIMS: The aim of this study was to compare the histopathological characteristics of these lesions and their risks for submucosal carcinoma. METHODS: This is a retrospective, cross-sectional, and observational study comparing 217 superficially elevated serrated lesions larger than 5 mm resected by colonoscopies (G1) with 558 depressed lesions (G2). RESULTS: In G1, 217 lesions were found in 12,653 (1.7%) colonoscopies; in G2, 558 lesions were found in 36,174 (1.5%) colonoscopies. In G1, 63.4% were women and in G2, there was no gender predominance. The average size of G1 was 16.2 mm and G2 was 9.2 mm (p<0.001). G1 predominated on the proximal colon and G2 on the distal and rectum (p<0.001). In G1, there were 214 (98.6%) low-grade intramucosal neoplasia and 3 (1.4%) high-grade intramucosal neoplasia. Excluding 126 hyperplastic polyps and considering 91 sessile serrated adenomas in G1, we observed 88 (96.7%) low-grade intramucosal neoplasia and 3 (3.3%) high-grade intramucosal neoplasia; in G2, we observed 417 (74.7%) low-grade intramucosal neoplasia, 113 (20.3%) high-grade intramucosal neoplasia, and 28 (5.0%) submucosal adenocarcinomas (p<0.001). CONCLUSION: Depressed lesions significantly had more high-grade intramucosal neoplasia and more invasive carcinomas in the submucosal layer than superficially elevated serrated lesions and more than superficially elevated sessile serrated adenomas.
dc.description.volume35
dc.identifier.doi10.1590/0102-672020220002e1716
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/39501
dc.relation.ispartofArquivos Brasileiros de Cirurgia Digestiva
dc.rightsAcesso Aberto
dc.subject.otherlanguageColon
dc.subject.otherlanguageColonoscopy
dc.subject.otherlanguageColorectal Neoplasms
dc.subject.otherlanguageMass Screening
dc.subject.otherlanguagePolyps
dc.titleWhich lesions are at higher risk of developing colorectal carcinomas: Superficially elevated serrated lesions or depressed lesions? QUAIS LESÕES APRESENTAM MAIOR RISCO DE EVOLUÇÃO PARA CARCINOMAS COLORRETAIS: AS SERRILHADAS SUPERFICIALMENTE ELEVADAS OU AS DEPRIMIDAS?
dc.typeArtigo
local.scopus.citations2
local.scopus.eid2-s2.0-85146193697
local.scopus.subjectAdenoma
local.scopus.subjectCarcinoma
local.scopus.subjectColonic Polyps
local.scopus.subjectColonoscopy
local.scopus.subjectColorectal Neoplasms
local.scopus.subjectCross-Sectional Studies
local.scopus.subjectFemale
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectRetrospective Studies
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85146193697&origin=inward
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