A sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury

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dc.contributor.authorFregni F.
dc.contributor.authorBoggio P.S.
dc.contributor.authorLima M.C.
dc.contributor.authorFerreira M.J.L.
dc.contributor.authorWagner T.
dc.contributor.authorRigonatti S.P.
dc.contributor.authorCastro A.W.
dc.contributor.authorSouza D.R.
dc.contributor.authorRiberto M.
dc.contributor.authorFreedman S.D.
dc.contributor.authorNitsche M.A.
dc.contributor.authorPascual-Leone A.
dc.date.accessioned2024-03-13T01:42:31Z
dc.date.available2024-03-13T01:42:31Z
dc.date.issued2006
dc.description.abstractPast evidence has shown that motor cortical stimulation with invasive and non-invasive brain stimulation is effective to relieve central pain. Here we aimed to study the effects of another, very safe technique of non-invasive brain stimulation - transcranial direct current stimulation (tDCS) - on pain control in patients with central pain due to traumatic spinal cord injury. Patients were randomized to receive sham or active motor tDCS (2 mA, 20 min for 5 consecutive days). A blinded evaluator rated the pain using the visual analogue scale for pain, Clinician Global Impression and Patient Global Assessment. Safety was assessed with a neuropsychological battery and confounders with the evaluation of depression and anxiety changes. There was a significant pain improvement after active anodal stimulation of the motor cortex, but not after sham stimulation. These results were not confounded by depression or anxiety changes. Furthermore, cognitive performance was not significantly changed throughout the trial in both treatment groups. The results of our study suggest that this new approach of cortical stimulation can be effective to control pain in patients with spinal cord lesion. We discuss potential mechanisms for pain amelioration after tDCS, such as a secondary modulation of thalamic nuclei activity. © 2006 International Association for the Study of Pain.
dc.description.firstpage197
dc.description.issuenumber1-2
dc.description.lastpage209
dc.description.volume122
dc.identifier.doi10.1016/j.pain.2006.02.023
dc.identifier.issn0304-3959
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37791
dc.relation.ispartofPain
dc.rightsAcesso Restrito
dc.subject.otherlanguageBrain polarization
dc.subject.otherlanguageCentral pain
dc.subject.otherlanguageSpinal cord injury
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleA sham-controlled, phase II trial of transcranial direct current stimulation for the treatment of central pain in traumatic spinal cord injury
dc.typeArtigo
local.scopus.citations595
local.scopus.eid2-s2.0-33646019827
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33646019827&origin=inward
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