Modulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC)

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dc.contributor.authorBoggio P.S.
dc.contributor.authorZaghi S.
dc.contributor.authorVillani A.B.
dc.contributor.authorFecteau S.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:30:34Z
dc.date.available2024-03-13T01:30:34Z
dc.date.issued2010
dc.description.abstractCognitive deficits that are reported in heavy marijuana users (attention, memory, affect perception, decision-making) appear to be completely reversible after a prolonged abstinence period of about 28 days. However, it remains unclear whether the reversibility of these cognitive deficits indicates that (1) chronic marijuana use is not associated with long-lasting changes in cortical networks or (2) that such changes occur but the brain adapts to and compensates for the drug-induced changes. Therefore, we examined whether chronic marijuana smokers would demonstrate a differential pattern of response in comparison to healthy volunteers on a decision-making paradigm (Risk Task) while undergoing sham or active transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC). Twenty-five chronic marijuana users who were abstinent for at least 24. h were randomly assigned to receive left anodal/right cathodal tDCS of DLPFC (n=8), right anodal/left cathodal tDCS of DLPFC (n=9), or sham stimulation (n=8); results on Risk Task during sham/active tDCS were compared to healthy volunteers from a previously published dataset. Chronic marijuana users demonstrated more conservative (i.e. less risky) decision-making during sham stimulation. While right anodal stimulation of the DLPFC enhanced conservative decision-making in healthy volunteers, both right anodal and left anodal DLPFC stimulation increased the propensity for risk-taking in marijuana users. These findings reveal alterations in the decision-making neural networks among chronic marijuana users. Finally, we also assessed the effects of tDCS on marijuana craving and observed that right anodal/left cathodal tDCS of DLPFC is significantly associated with a diminished craving for marijuana. © 2010 Elsevier Ireland Ltd.
dc.description.firstpage220
dc.description.issuenumber3
dc.description.lastpage225
dc.description.volume112
dc.identifier.doi10.1016/j.drugalcdep.2010.06.019
dc.identifier.issn0376-8716
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37131
dc.relation.ispartofDrug and Alcohol Dependence
dc.rightsAcesso Restrito
dc.subject.otherlanguageCognitive effects
dc.subject.otherlanguageDecision-making
dc.subject.otherlanguageMarijuana
dc.subject.otherlanguageNon-invasive brain stimulation
dc.subject.otherlanguageRisk
dc.subject.otherlanguageTranscranial direct current stimulation
dc.titleModulation of risk-taking in marijuana users by transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex (DLPFC)
dc.typeArtigo
local.scopus.citations159
local.scopus.eid2-s2.0-78649660279
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=78649660279&origin=inward
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