Feature-based molecular network-guided dereplication of natural bioactive products from leaves of stryphnodendron pulcherrimum (Willd.) hochr

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dc.contributor.authorGomes P.
dc.contributor.authorQuiros-Guerrero L.
dc.contributor.authorSilva C.
dc.contributor.authorPamplona S.
dc.contributor.authorBoutin J.A.
dc.contributor.authorEberlin M.
dc.contributor.authorWolfender J.-L.
dc.contributor.authorSilva M.
dc.date.accessioned2024-03-12T19:20:37Z
dc.date.available2024-03-12T19:20:37Z
dc.date.issued2021
dc.description.abstract© 2021 by the authors.Stryphnodendron pulcherrimum is a species known to have a high content of tannins. Accordingly, its preparations are used in southern Pará, Brazil, for their anti-inflammatory and antimicrobial activities, but so far, its chemical profile composition remains essentially unknown. We herein describe the compounds present in a hydro-acetonic extract from S. pulcherrimum leaves as revealed by dereplication via ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry. The data were combined with spectral organization, spectral matching through the Global Natural Products Social platform, in silico annotation and taxonomical ponderation. Several types of phenolic compounds were identified such as gallic acids, flavan-3-ols and flavone-like compounds. From these, 5 have been recently reported by our group, whereas 44 are reported here for the first time in this tree species, and 41 (out of 49) for this genus. The results highlight the possible role of Stryphnodendron pulcherrimum as a renewable source for natural bioactive products with potential pharmaceutical applications.
dc.description.issuenumber5
dc.description.volume11
dc.identifier.doi10.3390/metabo11050281
dc.identifier.issn2218-1989
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34665
dc.relation.ispartofMetabolites
dc.rightsAcesso Aberto
dc.subject.otherlanguageDereplication
dc.subject.otherlanguageMolecular network
dc.subject.otherlanguageStryphnodendron
dc.subject.otherlanguageUHPLC-MS/MS
dc.titleFeature-based molecular network-guided dereplication of natural bioactive products from leaves of stryphnodendron pulcherrimum (Willd.) hochr
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-85105668348
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85105668348&origin=inward
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