Klebsiella ESBL bacteremia-mortality and risk factors

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dc.contributor.authorFrancisco Tuon F.
dc.contributor.authorKruger M.
dc.contributor.authorTerreri M.
dc.contributor.authorPenteado-Filho S.R.
dc.contributor.authorGortz L.
dc.date.accessioned2024-03-13T01:10:11Z
dc.date.available2024-03-13T01:10:11Z
dc.date.issued2011
dc.description.abstractBackground: Extended spectrum β-lactamase (ESBL)-producing bacteria have become recognized as a problem in South America. The aim of this study was to evaluate risk factors and mortality rate in bacteremia caused by ESBL-producing Klebsiella pneumoniae in a Brazilian hospital. Methods: A three-year retrospective cohort study with 104 cases of K. pneumoniae bacteremia (61 ESBL and 43 non-ESBL). Several clinical and laboratory variables were evaluated. The outcome of interest was 30-day mortality. The adequate treatment was evaluated according to antibiotic susceptibility. Results: Multivariable analysis showed that central venous catheter and mechanical ventilation were independent risk factors for ESBL. The duration of hospitalization before the bacteremia was not a risk factor. Mortality was similar in ESBL and non-ESBL and inadequate therapy was not shown to be a risk factor. Conclusion: ESBL-producing Klebsiella bacteremia can occur early, suggesting that a carbapenem should be included in the initial empirical therapy for bacteremia in patients under mechanical ventilation and/or central venous catheter in our institution. © 2011 Elsevier Editora Ltda..
dc.description.firstpage594
dc.description.issuenumber6
dc.description.lastpage598
dc.description.volume15
dc.identifier.doi10.1016/S1413-8670(11)70257-4
dc.identifier.issn1413-8670
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36927
dc.relation.ispartofBrazilian Journal of Infectious Diseases
dc.rightsAcesso Aberto
dc.subject.otherlanguageBacteremia
dc.subject.otherlanguageBeta-lactamases
dc.subject.otherlanguageCarbapenems
dc.subject.otherlanguageKlebsiella pneumoniae
dc.titleKlebsiella ESBL bacteremia-mortality and risk factors
dc.typeArtigo
local.scopus.citations45
local.scopus.eid2-s2.0-84855930837
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84855930837&origin=inward
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