A randomized clinical trial of repetitive transcranial magnetic stimulation in patients with refractory epilepsy

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dc.contributor.authorFregni F.
dc.contributor.authorOtachi P.T.M.
dc.contributor.authorDo Valle A.
dc.contributor.authorBoggio P.S.
dc.contributor.authorThut G.
dc.contributor.authorRigonatti S.P.
dc.contributor.authorPascual-Leone A.
dc.contributor.authorValente K.D.
dc.date.accessioned2024-03-13T01:41:56Z
dc.date.available2024-03-13T01:41:56Z
dc.date.issued2006
dc.description.abstractObjective: To study the antiepileptic effects of rTMS in patients with refractory epilepsy and malformations of cortical development in a randomized, double-blind, sham-controlled trial. Methods: Twenty-one patients with malformations of cortical development and refractory epilepsy underwent five consecutive sessions of low-frequency rTMS, either sham or active (1Hz, 1,200 pulses), focally targeting the malformations of cortical development. The number of epileptiform discharges in the electroencephalogram and the number of clinical seizures were measured before (baseline), immediately after, as well as 30 and 60 days after rTMS treatment. Results: rTMS significantly decreased the number of seizures in the active compared with sham rTMS group (p < 0.0001), and this effect lasted for at least 2 months. Furthermore, there was a significant decrease in the number of epileptiform discharges immediately after (p = 0.01) and at week 4 (p = 0.03) in the active rTMS group only. There were few mild adverse effects equally distributed in both groups. The preliminary cognitive evaluation suggests improvement in some aspects of cognition in the active rTMS group only. Interpretation: Noninvasive brain stimulation for epilepsy may be an alternative treatment for pharmaco-resistant patients with clearly identifiable seizure foci in the cortical convexity and who are not eligible for surgical treatment. © 2006 American Neurological Association Published by Wiley-Liss, Inc., through Wiley Subscription Services.
dc.description.firstpage447
dc.description.issuenumber4
dc.description.lastpage455
dc.description.volume60
dc.identifier.doi10.1002/ana.20950
dc.identifier.issn0364-5134
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37759
dc.relation.ispartofAnnals of Neurology
dc.rightsAcesso Restrito
dc.titleA randomized clinical trial of repetitive transcranial magnetic stimulation in patients with refractory epilepsy
dc.typeArtigo
local.scopus.citations196
local.scopus.eid2-s2.0-33750589652
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=33750589652&origin=inward
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