Autoantibodies in scleroderma and their association with the clinical profile of the disease. A study of 66 patients from southern Brazil Autoanticorpos em esclerodermia e sua associação ao perfil clínico da doença. Estudo em 66 pacientes do sul do Brasil

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dc.contributor.authorSkare T.L.
dc.contributor.authorFonseca A.E.
dc.contributor.authorLuciano A.C.
dc.contributor.authorAzevedo P.M.
dc.date.accessioned2024-03-13T01:29:06Z
dc.date.available2024-03-13T01:29:06Z
dc.date.issued2011
dc.description.abstractBackground: Scleroderma is a fairly rare connective tissue disease whose autoantibody profile is associated with different clinical manifestations. The prevalence of autoantibodies in scleroderma is influenced by race and genetics. Objective: To study the prevalence of anti-Scl-70, anti-centromere (ACA) and anti-U1-RNP antibodies in patients with scleroderma in southern Brazil and verify their association with clinical manifestations of the disease. Methods: A retrospective study involving 66 patients with scleroderma for the presence of anti-Scl-70, anti-centromere and anti-U1-RNP and of clinical manifestations such as Raynaud's phenomenon, digital micro scars, digital necrosis, telangiectasias, calcinosis, pulmonary fibrosis, pleuritis, pericarditis, cardiomyopathy, arthralgia and arthritis, skin sclerosis, joint contractures, tendon friction rubs, pulmonary hypertension, esophageal disorders and renal crisis. Results: The prevalence of anti-Scl-70 was 17.8%, that of ACA was 33.3% and the prevalence of U1 RNP was 11.8%. Anti-Scl-70 was associated with the diffuse form of the disease (p = 0.015), presence of cardiomyopathies (p = 0.016) and digital micro scars (p = 0.05). Anti-centromere was more common in the limited form, although it was not statistically significant, and had a protective role associated with cardiomyopathies (p = 0.005). Anti-U1-RNP was more common in the overlap forms (p = 0.0004). Conclusion: The prevalence and profile of clinical associations of autoantibodies in Brazilian patients with scleroderma are similar to those found in the literature. © 2011 by Anais Brasileiros de Dermatologia.
dc.description.firstpage1075
dc.description.issuenumber6
dc.description.lastpage1081
dc.description.volume86
dc.identifier.doi10.1590/s0365-05962011000600003
dc.identifier.issn1806-4841
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37048
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsAcesso Aberto
dc.subject.otherlanguageAntibodies
dc.subject.otherlanguageAntinuclear
dc.subject.otherlanguageDiffuse
dc.subject.otherlanguageLimited
dc.subject.otherlanguageScleroderma
dc.titleAutoantibodies in scleroderma and their association with the clinical profile of the disease. A study of 66 patients from southern Brazil Autoanticorpos em esclerodermia e sua associação ao perfil clínico da doença. Estudo em 66 pacientes do sul do Brasil
dc.typeArtigo
local.scopus.citations22
local.scopus.eid2-s2.0-84856601756
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84856601756&origin=inward
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