Biodegradable scaffold: integration of polylactic acid, hydroxyapatite, and graphene oxide via FDM 3D printing

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dc.contributor.authorSiqueira A.S.
dc.contributor.authorBraga N.F.
dc.contributor.authorMunoz P.A.R.
dc.contributor.authorde Freitas L.F.
dc.contributor.authorFerreira A.H.
dc.contributor.authorFechine G.J.M.
dc.date.accessioned2024-06-01T06:11:01Z
dc.date.available2024-06-01T06:11:01Z
dc.date.issued2024
dc.description.abstract© 2024, BME-PT and GTE. All rights reserved.Extensive research and practical applications have been conducted within the biomaterials domain, focusing on polylactic acid (PLA) based composite. These composites have been explored for their favorable attributes, such as excellent processability, biodegradability, and bioactivity properties, but still lack mechanical properties. In this work, PLA-based nanocomposites were prepared by incorporating hydroxyapatite (HA) and graphene oxide (GO) via melt mixing (extruder). Filaments were obtained to develop scaffolds through 3D printing, utilizing the fused deposition method (FDM). The GO was produced using Hummer’s method and characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Raman Spectroscopy. The composites were analyzed using Fourier-transform infrared spectroscopy (FTIR), molecular weight, contact angle measurements, and thermal, mechanical, and rheological analysis. Adding only 0.05 wt% of GO to both PLA and PLA/HA resulted in enhancements in mechanical properties, particularly tensile strength, and significantly modified the surface properties of the materials studied. Specifically, formulation involving PLA/HA/GO was the only one to exhibit rheological properties compatible with the scaffold production process via FDM. These specific formulations were also investigated regarding cytotoxicity, and the presence of GO induces good cytocompatibility in mouse osteoblast cells (MC3T3). These results suggest that FDM technology can be used to fabricate higher-performance (mechanical and biological) scaffolds for tissue engineering.
dc.description.firstpage656
dc.description.issuenumber6
dc.description.lastpage672
dc.description.volume18
dc.identifier.doi10.3144/expresspolymlett.2024.48
dc.identifier.issnNone
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/38725
dc.relation.ispartofExpress Polymer Letters
dc.rightsAcesso Aberto
dc.subject.otherlanguagefused deposition modeling
dc.subject.otherlanguagegraphene oxide
dc.subject.otherlanguagehydroxyapatite
dc.subject.otherlanguagepolylactic acid
dc.subject.otherlanguagescaffold
dc.titleBiodegradable scaffold: integration of polylactic acid, hydroxyapatite, and graphene oxide via FDM 3D printing
dc.typeArtigo
local.scopus.citations1
local.scopus.eid2-s2.0-85191353989
local.scopus.subject3-D printing
local.scopus.subject3D-printing
local.scopus.subjectBiodegradable scaffold
local.scopus.subjectDeposition methods
local.scopus.subjectGraphene oxides
local.scopus.subjectMelt mixing
local.scopus.subjectPolylactic acid
local.scopus.subjectProcessability
local.scopus.subjectProperty
local.scopus.subjectS-method
local.scopus.updated2025-04-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85191353989&origin=inward
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