Leukopenia and thrombocytopenia induced by etanercept: Two case reports and literature review
Tipo
Artigo de revisão
Data de publicação
2012
Periódico
Revista Brasileira de Reumatologia
Citações (Scopus)
20
Autores
Azevedo V.F.
Silva M.B.G.
Marinello D.K.
dos Santos F.D.
Silva G.B.G.
Silva M.B.G.
Marinello D.K.
dos Santos F.D.
Silva G.B.G.
Orientador
Título da Revista
ISSN da Revista
Título de Volume
Membros da banca
Programa
Resumo
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine, and its excess can lead to severe consequences. Those effects are known to be antagonized by TNF-alpha inhibitors. Etanercept is a fusion protein that inhibits TNF-alpha action. As TNF-alpha regulation is related to cellular differentiation of various cellular types involved in immune response through expression of several other cytokines, it is possible that the use of its inhibitors may cause cytopenia. We report two cases of bicytopenia induced by etanercept. Both cases recovered after drug withdrawal. We discuss the need of introduction of routine laboratorial tests in patients using anti-TNF therapy, in order to identify possible hematological changes. © 2012 Elsevier Editora Ltda. All rights reserved.