Conditions for pathogen elimination by immune systems

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dc.contributor.authorChaui-Berlinck J.G.
dc.contributor.authorBarbuto J.A.M.
dc.contributor.authorMonteiro L.H.A.
dc.date.accessioned2024-03-13T01:45:14Z
dc.date.available2024-03-13T01:45:14Z
dc.date.issued2004
dc.description.abstractA continuous harvest effort can lead a population to extinction. How an "unconscious" immune system would perpetrate such an effort in order to eliminate a self-replicating antigen (a pathogen) becomes an intriguing problem if the system responses are functions of the pathogen population: the responses cannot be a continuous effort as the pathogen vanishes. On theoretical grounds, we show some qualities an immune response must have to support pathogen elimination. Then, three specific mechanisms are addressed: a pathogen-independent positive feedback loop among the responding cells of the system (e.g., B-lymphocyte and T-helper); the persistence of antigen bound to presenting cells; and the programmed expansion/ contraction of a pool of responding cells. The maintenance of responding cells due to these mechanisms is the essential feature to the effective clearance of self-replicating agents. Thus, evolutionarily, the primary function of a helper lymphocyte would be to amplify a response and the primary function of memory would be the very elimination of pathogens. © 2004 Elsevier GmbH. All rights reserved.
dc.description.firstpage195
dc.description.issuenumber2
dc.description.lastpage208
dc.description.volume123
dc.identifier.doi10.1016/j.thbio.2004.01.001
dc.identifier.issn1431-7613
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37941
dc.relation.ispartofTheory in Biosciences
dc.rightsAcesso Restrito
dc.subject.otherlanguageAntigen persistence
dc.subject.otherlanguageImmunological memory
dc.subject.otherlanguageLymphocytes surveillance level
dc.subject.otherlanguagePositive feedback loops
dc.subject.otherlanguageProgrammed expansion/contraction of cellular pools
dc.titleConditions for pathogen elimination by immune systems
dc.typeArtigo
local.scopus.citations8
local.scopus.eid2-s2.0-4644316930
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=4644316930&origin=inward
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