Fish oil attenuates methylmalonate-induced seizures

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dc.contributor.authorBandero C.R.R.
dc.contributor.authorSalvadori M.G.S.S.
dc.contributor.authorGomes A.T.
dc.contributor.authorDal Ri N.M.K.
dc.contributor.authorFurian A.F.
dc.contributor.authorOliveira M.S.
dc.contributor.authorRambo L.M.
dc.contributor.authorScorza F.A.
dc.contributor.authorCysneiros R.M.
dc.contributor.authorEmanuelli T.
dc.contributor.authorMello C.F.
dc.date.accessioned2024-03-13T01:04:25Z
dc.date.available2024-03-13T01:04:25Z
dc.date.issued2013
dc.description.abstractMethylmalonic acidemias are inherited metabolic disorders characterized by methylmalonate (MMA) accumulation and neurological dysfunction, including seizures. Dietary fatty acids are known as an important energy source and reduce seizure activity in selected acute animal models. This study investigated whether chronic treatment with fish oil or with oleic acid attenuates MMA-induced seizures and whether maintenance of Na+,K+-ATPase activity was involved in such an effect. Adult male Wistar rats were given fish oil (85mg/kg), oleic acid (85mg/kg) or vehicle (0.42% aqueous Cremophor EL™, 4mL/kg/body weight/day), p.o., for 75 days. On the 73th day a cannula was implanted in the right lateral ventricle with electrodes over the parietal cortex for EEG recording. On the 76th day the animals were injected with NaCl (2.5μmol/2.5μL, i.c.v.), or with MMA (2.5μmol/2.5μL, i.c.v.), and seizure activity was measured by electroencephagraphic (EEG) recording with concomitant behavior monitoring. The effect of prostaglandin E2 (PGE2) on Na+,K+-ATPase activity of slices of cerebral cortex from NaCl-injected animals was determined. Fish oil increased the latency to MMA-induced tonic-clonic seizures, reduced the mean amplitude of ictal EEG recordings, and prevented PGE2-induced decrease of Na+,K+-ATPase activity in cortical slices in vitro. Oleic acid decreased mean amplitude of ictal EEG recordings. The results support that fish oil decreases MMA-induced seizures. The decreased sensitivity of Na+,K+-ATPase to the inhibitory effect of PGE2in fish oil-treated animals may be related to the currently reported anticonvulsant activity. © 2013 Elsevier B.V.
dc.description.firstpage69
dc.description.issuenumber1-2
dc.description.lastpage76
dc.description.volume105
dc.identifier.doi10.1016/j.eplepsyres.2013.01.005
dc.identifier.issn0920-1211
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36602
dc.relation.ispartofEpilepsy Research
dc.rightsAcesso Restrito
dc.subject.otherlanguageFatty acid
dc.subject.otherlanguageFish oil
dc.subject.otherlanguageMethylmalonate
dc.subject.otherlanguageOleic acid
dc.subject.otherlanguageSeizure
dc.titleFish oil attenuates methylmalonate-induced seizures
dc.typeArtigo
local.scopus.citations15
local.scopus.eid2-s2.0-84878447362
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84878447362&origin=inward
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