Antifungals discovery: an insight into new strategies to combat antifungal resistance

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dc.contributor.authorFuentefria A.M.
dc.contributor.authorPippi B.
dc.contributor.authorDalla Lana D.F.
dc.contributor.authorDonato K.K.
dc.contributor.authorde Andrade S.F.
dc.date.accessioned2024-03-13T00:00:00Z
dc.date.available2024-03-13T00:00:00Z
dc.date.issued2018
dc.description.abstract© 2017 The Society for Applied MicrobiologyUndeniably, new antifungal treatments are necessary against pathogenic fungi. Fungal infections have significantly increased in recent decades, being highlighted as important causes of morbidity and mortality, particularly in immunocompromised patients. Five main antifungal classes are used: (i) azoles, (ii) echinocandins, (iii) polyenes, (iv) allylamines and (v) pyrimidine analogues. Moreover, the treatment of mycoses has several limitations, such as undesirable side effects, narrow activity spectrum, a small number of targets and fungal resistance, which are still of major concern in clinical practice. The discovery of new antifungals is mostly achieved by the screening of natural or synthetic/semisynthetic chemical compounds. The most recent discoveries in drug resistance mechanism and their avoidance were explored in a review, focusing on different antifungal targets, as well as new agents or strategies, such as combination therapy, that could improve antifungal therapy. Significance and Impact of the Study: The failure to respond to antifungal therapy is complex and is associated with microbiological resistance and increased expression of virulence in fungal pathogens. Thus, this review offers an overview of current challenges in the treatment of fungal infections associated with increased antifungal drug resistance and the formation of biofilms in these opportunistic pathogens. Furthermore, the most recent and potential strategies to combat fungal pathogens are explored here, focusing on new agents as well as innovative approaches, such as combination therapy between antifungal drugs or with natural compounds.
dc.description.firstpage2
dc.description.issuenumber1
dc.description.lastpage13
dc.description.volume66
dc.identifier.doi10.1111/lam.12820
dc.identifier.issn0266-8254
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35651
dc.relation.ispartofLetters in Applied Microbiology
dc.rightsAcesso Aberto
dc.subject.otherlanguageantifungals
dc.subject.otherlanguagecombination therapy
dc.subject.otherlanguagefungal resistance
dc.subject.otherlanguagenatural and synthetic drugs
dc.subject.otherlanguagesynergistic action
dc.titleAntifungals discovery: an insight into new strategies to combat antifungal resistance
dc.typeArtigo de revisão
local.scopus.citations117
local.scopus.eid2-s2.0-85038562866
local.scopus.subjectAntifungal drugs
local.scopus.subjectAntifungals
local.scopus.subjectCombination therapy
local.scopus.subjectDrug-resistance
local.scopus.subjectFungal infection
local.scopus.subjectFungal pathogen
local.scopus.subjectFungal resistances
local.scopus.subjectNatural and synthetic drug
local.scopus.subjectSynergistic action
local.scopus.subjectSynthetic drug
local.scopus.subjectAnimals
local.scopus.subjectAntifungal Agents
local.scopus.subjectDrug Discovery
local.scopus.subjectDrug Resistance, Fungal
local.scopus.subjectFungi
local.scopus.subjectHumans
local.scopus.subjectMycoses
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85038562866&origin=inward
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