Mannose-binding lectin deficiency and miscarriages in rheumatoid arthritis

Página do item simplificado
dc.contributor.authorCieslinski J.Z.
dc.contributor.authorGoeldner I.
dc.contributor.authorSkare T.L.
dc.contributor.authorNisihara R.
dc.contributor.authorAndrade F.A.D.
dc.contributor.authorVelavan T.P.
dc.contributor.authorMessias-Reason I.
dc.contributor.authorUtiyama S.R.R.
dc.date.accessioned2024-03-13T00:48:20Z
dc.date.available2024-03-13T00:48:20Z
dc.date.issued2017
dc.description.abstract© 2017 Informa UK Limited, trading as Taylor & Francis Group.Objective: To investigate the association between mannose-binding lectin (MBL) serum level and MBL2 polymorphisms, and the frequency of spontaneous miscarriages in rheumatoid arthritis (RA) patients. Methods: One hundred seventy seven women (mean age 50 years) with RA from Southern Brazil were studied and 4.5% had a history of abortion (8/177). The MBL levels were determined by ELISA. MBL2 polymorphisms in the promoter (−550H/L, −221X/Y), 5′ untranslated region (4 P/Q) and exon 1 (p.Gly54Asp: B allele, p.Arg52Cys: D allele and p.Gly57Glu: C allele; collectively labelled O) were genotyped by sequencing. Results: Mannose-binding lectin levels of RA patients ranged from ≤100 ng/mL to 6640 ng/mL (median 541.5 ng/mL). There was a significant difference in MBL median levels (100 ng/mL vs. 625 ng/mL, respectively, p =.001) and frequency of MBL deficiency (75.0% vs. 24.1%, p =.007, OR = 10.3, 95%CI = 1.9–55.4), in patients with a history of miscarriage vs those without it. Patients with RA and miscarriage had more frequently haplotypes related with low MBL levels (p =.007, OR = 10.5, 95%CI = 1.3–84) than high producers. Moreover, LYPB haplotype and O allele were significantly associated with the occurrence of miscarriage (p =.001, OR = 9.7, 95%CI = 2.4–39.1 and p =.009, OR = 5.9, 95%CI = 1.4–23.4, respectively). Conclusions: The results suggest that MBL deficiency and the presence of MBL2 gene polymorphisms that lead to MBL deficiency are risk factors for the occurrence of miscarriage in patients with RA.
dc.description.firstpage409
dc.description.issuenumber7
dc.description.lastpage413
dc.description.volume50
dc.identifier.doi10.1080/08916934.2017.1373765
dc.identifier.issn0891-6934
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/35707
dc.relation.ispartofAutoimmunity
dc.rightsAcesso Restrito
dc.subject.otherlanguagemannose-binding lectin
dc.subject.otherlanguagemiscarriage
dc.subject.otherlanguageRheumatoid arthritis
dc.titleMannose-binding lectin deficiency and miscarriages in rheumatoid arthritis
dc.typeArtigo
local.scopus.citations7
local.scopus.eid2-s2.0-85029421606
local.scopus.subjectAbortion, Spontaneous
local.scopus.subjectAdult
local.scopus.subjectAlleles
local.scopus.subjectAmino Acid Substitution
local.scopus.subjectArthritis, Rheumatoid
local.scopus.subjectBiomarkers
local.scopus.subjectFemale
local.scopus.subjectGenotype
local.scopus.subjectHaplotypes
local.scopus.subjectHumans
local.scopus.subjectMale
local.scopus.subjectMannose-Binding Lectin
local.scopus.subjectMetabolism, Inborn Errors
local.scopus.subjectMiddle Aged
local.scopus.subjectOdds Ratio
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85029421606&origin=inward
Arquivos
Coleções
Artigos de periódico