Perinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring

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dc.contributor.authorTeodorov E.
dc.contributor.authorMoraes A.P.
dc.contributor.authorFelicio L.F.
dc.contributor.authorVarolli F.M.
dc.contributor.authorBernardi M.M.
dc.date.accessioned2024-03-13T01:43:57Z
dc.date.available2024-03-13T01:43:57Z
dc.date.issued2005
dc.description.abstractA previous study in our laboratory showed that perinatal maternal picrotoxin exposure (0.75 mg/kg) in rats improved heterosexual behavior in male offspring. In the present study, we examined the effects of this maternal treatment on sexual behavior in the female offspring. The dams received 0.75 mg/kg picrotoxin treatment (PT) once a day on the 18th and 21th day of pregnancy, 2 h after parturition and once a day during the first 4 days of lactation. The results showed that (1) at birth, the body weight and anogenital distance were not modified by treatment; (2) female sexual behavior was improved in experimental animals. These results demonstrate that perinatal picrotoxin exposure improves adult sexual behavior in female rat offspring as suggested by increase in the lordosis quotient. © 2005 Elsevier Inc. All rights reserved.
dc.description.firstpage935
dc.description.issuenumber4
dc.description.lastpage942
dc.description.volume81
dc.identifier.doi10.1016/j.pbb.2005.07.002
dc.identifier.issn0091-3057
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37870
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.rightsAcesso Restrito
dc.subject.otherlanguageDopamine
dc.subject.otherlanguageFertility
dc.subject.otherlanguageGABA
dc.subject.otherlanguagePerinatal toxicology
dc.subject.otherlanguageReproductive behavior
dc.subject.otherlanguageSexual development
dc.subject.otherlanguageStress
dc.titlePerinatal maternal exposure to picrotoxin: Effects on sexual behavior in female rat offspring
dc.typeArtigo
local.scopus.citations4
local.scopus.eid2-s2.0-23944509226
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=23944509226&origin=inward
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