Can the 'yin and yang' BDNF hypothesis be used to predict the effects of rTMS treatment in neuropsychiatry?

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dc.contributor.authorBrunoni A.R.
dc.contributor.authorBoggio P.S.
dc.contributor.authorFregni F.
dc.date.accessioned2024-03-13T01:37:22Z
dc.date.available2024-03-13T01:37:22Z
dc.date.issued2008
dc.description.abstractRepetitive transcranial magnetic stimulation (rTMS) is a novel technique of non-invasive brain stimulation which has been used to treat several neuropsychiatric disorders such as major depressive disorder, chronic pain and epilepsy. Recent studies have shown that the therapeutic effects of rTMS are associated with plastic changes in local and distant neural networks. In fact, it has been suggested that rTMS induces long-term potentiation (LTP) and long-term depression (LTD) - like effects. Besides the initial positive clinical results; the effects of rTMS are still mixed. Therefore new tools to assess the effects of plasticity non-invasively might be useful to predict its therapeutic effects and design novel therapeutic approaches using rTMS. In this paper we propose that brain-derived neurotrophic factor (BDNF) might be such a tool. Brain-derived neurotrophic factor is a neurotrophin that plays a key role in neuronal survival and synaptic strength, which has also been studied in several neuropsychiatric disorders. There is robust evidence associating BDNF with the LTP/LTD processes, and indeed it has been proposed that BNDF might index an increase or decrease of brain activity - the 'yin and yang' BDNF hypothesis. In this article, we review the initial studies combining measurements of BDNF in rTMS clinical trials and discuss the results and potential usefulness of this instrument in the field of rTMS. © 2008 Elsevier Ltd. All rights reserved.
dc.description.firstpage279
dc.description.issuenumber2
dc.description.lastpage282
dc.description.volume71
dc.identifier.doi10.1016/j.mehy.2008.02.011
dc.identifier.issn0306-9877
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/37510
dc.relation.ispartofMedical Hypotheses
dc.rightsAcesso Restrito
dc.titleCan the 'yin and yang' BDNF hypothesis be used to predict the effects of rTMS treatment in neuropsychiatry?
dc.typeArtigo
local.scopus.citations25
local.scopus.eid2-s2.0-45649085654
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=45649085654&origin=inward
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