Timing of fructose intake: An important regulator of adiposity

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dc.contributor.authorMorris M.
dc.contributor.authorAraujo I.C.
dc.contributor.authorPohlman R.L.
dc.contributor.authorMarques M.C.
dc.contributor.authorRodwan N.S.
dc.contributor.authorFarah V.M.A.
dc.date.accessioned2024-03-13T01:09:30Z
dc.date.available2024-03-13T01:09:30Z
dc.date.issued2012
dc.description.abstract1.Overconsumption of fructose produces glucose intolerance, autonomic abnormalities and renal dysfunction and may be related to the worldwide epidemic of obesity and diabetes. 2.Experiments were conducted to determine whether the time period (light or dark) of fructose consumption influenced the pathological consequences. C57BL mice were given standard chow and assigned to one of three groups: (i) control (n=10), which received water over a 24h period; (ii) FL (n=11), which received 10% fructose solution during the 12h light period; and (iii) FD (n=11), which received 10% fructose solution during the 12h dark period. 3.There was a time related increase in body weight for all groups (P<0.01, 2 vs 6 wks). There was a greater increase in body fat in the FL group compared with the control and FD groups. The changes in adiposity occurred even though the total caloric intake was not significantly different among the groups (approximately 18kcal/day). Total fluid (water+fructose) consumption was greater in the FD and FL groups compared with control at 6weeks. Significant increases were noted for plasma insulin and leptin at 8weeks, with highest levels in the FL compared with FD group (P<0.05). There were no significant changes in glucose, glucose tolerance, cholesterol, triglycerides or adiponectin. 4.The results of the present study suggest that there is a mismatch in caloric consumption, metabolism and adiposity as related to the light-dark cycle of fructose consumption. These findings have clinical implications in the control of bodyweight, abdominal fat accumulation and Type 2 diabetes. © 2011 The Authors. Clinical and Experimental Pharmacology and Physiology © 2011 Blackwell Publishing Asia Pty Ltd.
dc.description.firstpage57
dc.description.issuenumber1
dc.description.lastpage62
dc.description.volume39
dc.identifier.doi10.1111/j.1440-1681.2011.05636.x
dc.identifier.issn0305-1870
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/36889
dc.relation.ispartofClinical and Experimental Pharmacology and Physiology
dc.rightsAcesso Restrito
dc.subject.otherlanguageBody fat
dc.subject.otherlanguageCircadian rhythm
dc.subject.otherlanguageDiabetes
dc.subject.otherlanguageInsulin
dc.subject.otherlanguageLeptin
dc.titleTiming of fructose intake: An important regulator of adiposity
dc.typeArtigo
local.scopus.citations19
local.scopus.eid2-s2.0-84855172232
local.scopus.updated2024-05-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84855172232&origin=inward
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