Liquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry

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dc.contributor.authorOliveira L.F.C.
dc.contributor.authorTega D.U.
dc.contributor.authorEberlin M.N.
dc.contributor.authorSussulini A.
dc.date.accessioned2024-03-12T19:15:42Z
dc.date.available2024-03-12T19:15:42Z
dc.date.issued2022
dc.description.abstract© 2021 Elsevier B.V.Venturi easy ambient sonic spray ionization (V-EASI) is a soft ambient ionization (AI) source that has the advantages of being suitable to the analysis of samples in solution (differently from the majority of AI sources), performing self-pumping, voltage- and heat-free ionization, and requiring minimum or no sample preparation. Since this ionization technique has not been fully explored, the present study provides a proof of principle of the coupling of liquid chromatography to mass spectrometry (LC-MS) using V-EASI as the interface. In order to test the performance of the developed LC-V-EASI-MS system, a quantification method for bixin, a natural dye from annatto (Bixa Orellana L.), which is known to be sensitive to the high voltage applied for electrospray ionization mass spectrometry (ESI-MS) analysis, was validated according to FDA criteria and tested in real samples. The analytical method was successfully applied and met the validation criteria, providing a detectability 10 times better than methods already reported to the quantification of bixin and no matrix effect was observed. Therefore, this proof of principle contributes to the continuous development of AI sources that represents the last great technological advance in MS towards becoming a miniaturized technique able to analyze samples closer to their actual state.
dc.description.volume238
dc.identifier.doi10.1016/j.talanta.2021.123004
dc.identifier.issn0039-9140
dc.identifier.urihttps://dspace.mackenzie.br/handle/10899/34402
dc.relation.ispartofTalanta
dc.rightsAcesso Restrito
dc.subject.otherlanguageAmbient ionization
dc.subject.otherlanguageAnalytical methods
dc.subject.otherlanguageAnnatto analysis
dc.subject.otherlanguageLiquid chromatography
dc.subject.otherlanguageMass spectrometry
dc.subject.otherlanguageVenturi easy ambient sonic-spray ionization mass spectrometry
dc.titleLiquid chromatography coupled to Venturi easy ambient sonic spray ionization mass spectrometry
dc.typeArtigo
local.scopus.citations3
local.scopus.eid2-s2.0-85118488864
local.scopus.subjectAmbient ionizations
local.scopus.subjectAnalytical method
local.scopus.subjectAnnatto analyse
local.scopus.subjectEasy ambient sonic spray ionizations
local.scopus.subjectIonisation sources
local.scopus.subjectIonization mass spectrometry
local.scopus.subjectProof of principles
local.scopus.subjectSelf-pumping
local.scopus.subjectVenturi
local.scopus.subjectVenturi easy ambient sonic-spray ionization mass spectrometry
local.scopus.subjectChromatography, Liquid
local.scopus.subjectSpectrometry, Mass, Electrospray Ionization
local.scopus.updated2024-12-01
local.scopus.urlhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85118488864&origin=inward
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